alpha-Synuclein is a major constituent of glial cytoplasmic inclusions (GCIs), which are pathognomic for multiple system atrophy (MSA). We have previously demonstrated that in normal human brain, alpha-synuclein mRNA has a restricted pattern of neuronal expression and no apparent glial expression. The current study used double-label in situ hybridization to determine if alpha-synuclein mRNA is ...

The statement that HIV co-infection is common (8 cases) and bacterial co-infection uncommon (7 cases) in this patient population seems not very objective. Please reconsider this statement. We have changed this to “Co-infection with HIV was relatively common but, compared to studies in children, bacteraemia was uncommon” Besides CAM and MSA another internationally established scoring tool (Lamba...

With the ability to study brain anatomy in vivo using magnetic resonance imaging, studies on regional brain atrophy suggest possible improvements for differential diagnosis of movement disorders with parkinsonian symptoms. In this study, we investigate effects of different parkinsonian syndromes on the cortical gray matter thickness and the geometric shape of the cerebral cortex. The study cons...

The current article has been inspired by the interdisciplinary set of lectures that were offered in terms of the Summer Academy on Economic Growth and Governance of Natural Resources in Lomonosov Moscow State University (MSA 2015, 20/07 01/08/2015), as well as by the recent developments in Arctic marine governance. Scholars with intimate knowledge of issues related to economic growth, resource ...

We introduce a generic Language Independent Framework for Linguistic Code Switch Point Detection. The system uses the word length, character level (1, 2, 3, 4, and 5)-grams and word level unigram language models to train a conditional random fields (CRF) model for classifying input words into various languages. We test our proposed framework and compare it to the state-of-theart published syste...

In this paper, we present a statistical machine translation system for English to Dialectal Arabic (DA), using Modern Standard Arabic (MSA) as a pivot. We create a core system to translate from English to MSA using a large bilingual parallel corpus. Then, we design two separate pathways for translation from MSA into DA: a two-step domain and dialect adaptation system and a one-step simultaneous...

The growth of bioinformatics and computational biology industry, multiple sequence alignment (MSA) applications have become an important emerging workload. In spite of the large amount of recent attention given to the MSA software design, there has been little quantitative understanding of the performance of such applications on modern microprocessors and systems. In this paper we try to analyz...

Over the last decade a prominent amount of studies in preclinical transgenic models of multiple system atrophy (MSA) has been performed. These studies have helped understand mechanisms downstream to the α-synuclein oligodendroglial accumulation relevant to human MSA. However, the successful translation of the preclinical outcomes into a clinical trial has failed. Looking back, we can now identi...

The majority of research on Arabic Named Entity Recognition (NER) addresses the the task for newswire genre, where the language used is Modern Standard Arabic (MSA), however, the need to study this task in social media is becoming more vital. Social media is characterized by the use of both MSA and Dialectal Arabic (DA), with often code switching between the two language varieties. Despite some...