PURPOSE To show whether an intra-articular (IA) infiltration of 1 mL sodium hyaluronate (SH) into the temporomandibular joint (TMJ) would significantly reduce pain and improve joint function in Wilkes stage II disease, compared with the oral administration of a combination of methocarbamol and paracetamol. PATIENTS AND METHODS Forty-one patients with Wilkes stage II disease were selected and ...

Polymorphic behaviours of paracetamol and propyphenazone and interaction between these two compounds were investigated using differential scanning calorimetry (DSC), X-ray powder diffraction and Fourier transform-infrared (FT-IR)-spectroscopy. Binary mixtures containing various ratios of the compounds were prepared as physical and fused mixtures and analysed by DSC to study their thermal behavi...

A high-performance liquid chromatography analytical procedure for the simultaneous determination of paracetamol and caffeine in a model tablet formulation has been developed. The separation was achieved on a C8 column at a flow rate of 1.0 ml/min with UV detection at 230 nm. The mobile phase was composed of 1mM phosphate buffer pH 7.0 – methanol (65:35 v/v). The method was validated through inv...

Paracetamol (acetaminophen) is the most common drug taken in overdose in the UK, accounting for 48% of poisoning admissions to hospital and being involved in an estimated 100-200 deaths per year. In 1998, the UK government introduced legislation that reduced the maximum pack size of all non-effervescent tablets and capsules containing aspirin (acetylsalicylic acid) or paracetamol that can be so...

Various commercially available paracetamol tablets (500 mg) were evaluated comparatively for in vitro dissolution qualities along with drug content (assay). The assay results ascertain the presence and compendial quality of paracetamol in all these products. The in vitro dissolution profiles were found to be varying for each tablet, but within the prescribed limit. The dissolution at 15 minutes...

A rapid and sensitive high performance liquid chromatography with UV detection method was developed and validated for the quantification of paracetamol, chlorzoxazone and aceclofenac in dosage forms. The chromatographic separation was carried out on a Phenomenex Luna C18 column using a mixture of acetonitrile-0.05M disodium hydrogen orthophosphate (65:35) (pH adjusted to 3.0 using 10% orthophos...

OBJECTIVE To compare the costs of treating osteoarthritis (OA) pain using combination tramadol/paracetamol tablets, Non-Steroidal Anti-Inflammatory Agents (NSAID) alone or NSAID plus proton pump inhibitors (PPI) from the perspective of the Spanish National Health System. METHODS A decision-analytical model was constructed to analyze the cost associated with three treatment strategies over 6 m...

Pharmaceutical Manufacturing is an important enterprise and oral tablet manufacturing is the most significant of all, because more drugs are made as tablets than any other dosage form. The way of tablet manufacturing has been undergoing change in recent years and is likely to head in new directions. In this study Tinospora cordifolia (guduchi) a freely available, a climbing shrub belonging to t...

The aim of the study was to develop UV-spectrophotometric and RP-HPLC methods for the simultaneous analysis of paracetamol and aceclofenac in marketed tablets. The methods were validated in terms of linearity, accuracy (% Recovery), precision (inter day, intraday and reproducibility) and robustness. Both the methods were linear (R = 0.997-0.999 for UV method and 0.999 for RP-HPLC method) and ac...