Renal monoclonal immunoglobulin deposition disease (MIDD) is a rare defined by of light chains and/or heavy on basement membranes and vascular walls the kidney. We describe case 71-year-old woman with kidney failure secondary to lambda in association plasma cell dyscrasia. Her initial serum protein electrophoresis did not demonstrate protein, classic cast nephropathy was absent renal biopsy. Ho...

ABSTRACT Background According to data from large national registries, almost 20%–25% of patients with end-stage kidney disease have an undetermined (UKD). Recent shown that monogenic disease-causing variants are under-diagnosed. We performed exome sequencing (ES) on UKD in our center improve the diagnosis rate. Methods ES was proposed routine practice for including biopsy January 2019 December ...

INTRODUCTION Percutaneous renal biopsy (PRB) is a safe and effective modality for sampling kidney tissue. In limited circumstances, alternative methods for kidney biopsy may be indicated. Historical contraindications for PRB such as bleeding diathesis, morbid obesity and solitary kidney have been called into question in the literature. We present a review of the literature on PRB and the risks ...

Assessing the initial severity of immunoglobulin A vasculitis nephritis (IgAV-N) is important due to its determining effect on kidney management and outcomes. This paper describes a multicentre paediatric cohort IgAV-N patients discusses relationships among clinical presentation, histological features, outcome. We retrospectively studied 170 children with biopsy-proven IgAV-N, diagnosed between...

Accumulated clinical data suggest that non-diabetic nephropathy complicating type 1 diabetes mellitus is rare, accounting for 2-3% of unselected diabetic patients with proteinuria. In contrast, non-diabetic kidney disease is a common finding in patients with type 2 diabetes mellitus. Joint analysis of available data on prevalence of non-diabetic kidney disease among type 2 diabetic patients rev...

Kidney fibrosis is the hallmark of chronic kidney disease (CKD) and characterized by an imbalanced extracellular matrix (ECM) remodeling. Collagen type III one main ECM components interstitial kidney. We hypothesized that measuring three biomarkers collagen reflecting different aspects this protein turnover (C3M, C3C, PRO-C3) may provide information about fibrotic burden in patients with IgA ne...

BACKGROUND The outcome of kidney allograft transplantation is associated with numerous donor-dependent and recipient-dependent immunological and non-immunological factors. Studies on genetic factors affecting the non-immunological aspects, like ageing of the kidney allograft and patient outcome are still lacking. The aim of this study was the analysis of relative telomere length (RTL; T/S ratio...