RNA interference (RNAi) is a powerful tool to analyze gene function in mammalian cells. However, the interpretation of RNAi knock-down phenotypes can be hampered by off-target effects or compound phenotypes, as many proteins combine multiple functions within one molecule and coordinate the assembly of multimolecular complexes. Replacing the endogenous protein with ectopic wild-type or mutant fo...

The paper describes correlation between combustion knock intensity and combustion rate calculated as the heat release rate from combustion pressure traces of a hydrogen fuelled spark ignited engine. Unlike a gasoline spark ignited (SI) engine, the hydrogen fuelled engine can easily generate knock during combustion at working conditions similar to a gasoline engine. However, the hydrogen knock d...

In this paper we consider signal processing algorithms for detecting knock, i.e. auto-ignition of unburned fuel, in spark-ignited engines. To operate an engine with optimal efficiency, there is a need to operate close to the knock limit. This motivates the need for efficient knock detection algorithms that not only indicates knock, but also gives estimates on knock timing and size. The proposed...

The Galactose-α1,3-galactose (α1,3Gal) epitope is responsible for hyperacute rejection in pig-to-human xenotransplantation. Human decay-accelerating factor (hDAF) is a cell surface regulatory protein that serves as a complement inhibitor to protect self cells from complement attack. The generation of α1,3-galactosyltransferase (GGTA1) knock-out pigs expressing DAF is a necessary step for their ...

Variable compression engines are a mean to meet the demand on lower fuel consumption. A high compression ratio results in high engine efficiency, but also increases the knock tendency. On conventional engines with fixed compression ratio, knock is avoided by retarding the ignition angle. The variable compression engine offers an extra dimension in knock control, since both ignition angle and co...

Piston engines fueled by kerosene have a strong application prospect in special vehicles and small aircrafts, but the low amount of octane fuel causes its knock combustion phenomenon to be particularly serious. A will deteriorate power economy engine damage serious cases. Therefore, knocking is key problem with engines. We propose knock-prediction system for based on in-cylinder pressure signal...