It is known that the opioid peptide dynorphin A has a broad distribution throughout the neuraxis. Recent biochemical studies have extended the sequence of dynorphin A by 15 amino acids to include another [Leu]enkephalin-containing peptide known as dynorphin B. These sequence data have been validated by the elucidation of the structure of the hypothalamic mRNA coding for alpha- and beta-neo-endo...

Previously this laboratory characterized Slc39a8-encoded ZIP8 as a Zn(2+)/(HCO(3)(-))(2) symporter; yet, the overall physiological importance of ZIP8 at the whole-organism level remains unclear. Herein we describe the phenotype of the hypomorphic Slc39a8(neo/neo) mouse which has retained the neomycin-resistance gene in intron 3, hence causing significantly decreased ZIP8 mRNA and protein levels...

the both atlantic side relations from the ancient time had been faced with too much challenge but the continuing of this relation is due to the common political and economical interests. the upper atlantic and the two organizations (nato, eu) still exist to gain the essential goals and the political and security connection which are boosting with the economical integration at the same time. but...

Rhodopsin is formed by the condensation of opsin with a cis isomer of retinene, called neo-b. The bleaching of rhodopsin releases all-trans retinene which must be isomerized back to neo-b in order for rhodopsin to regenerate. Both retinene isomers are in equilibrium with the corresponding isomers of vitamin A, through the alcohol dehydrogenase system. An enzyme is found in cattle retinas and fr...

The advent of a nationalist movement known as Neo-nationalism in India led to the history women's there. Gender concerns have been dropped from Neo-nationalist agenda order concentrate on lost Hindu identity that was influenced by nostalgic traditions past oppressed and subjugated women while celebrating role male figure. This paper covers description public activists who diverged social regula...

The precise identification of Human Leukocyte Antigen class I (HLA-I) binding motifs plays a central role in our ability to understand and predict (neo-)antigen presentation in infectious diseases and cancer. Here, by exploiting co-occurrence of HLA-I alleles across ten newly generated as well as forty public HLA peptidomics datasets comprising more than 115,000 unique peptides, we show that we...

The present study employed multivariate genetic item-level analyses to examine the ontology and the genetic and environmental etiology of the Big Five personality dimensions, as measured by the NEO Five Factor Inventory (NEO-FFI) [Costa and McCrae, Revised NEO personality inventory (NEO PI-R) and NEO five-factor inventory (NEO-FFI) professional manual, 1992; Hoekstra et al., NEO personality que...

The purpose of this paper is to re-address the vision of human-computer symbiosis as originally expressed by J.C.R. Licklider nearly a half-century ago and to argue for the relevance of this vision to the field of cognitive informatics. We describe this vision, place it in some historical context relating to the evolution of human factors research, and observe that the field is now in the proce...

How is it rational for us to form, maintain, and revise our intentions, in cases where we are not certain of what the outcomes of the available acts will be? The mental events in which we form or revise our intentions are choices or decisions. So, to answer this question, it is natural to look to the approach that has been developed by classical decision theory (also known as rational choice th...

Article history: Received 16 January 2014 Accepted 20 September 2014 Available online 22 October 2014 Submitted by Y. Wei MSC: 15A18 15A57