RATIONALE To assess the treatment progression during the 24 months following a formal diagnosis of chronic obstructive pulmonary disease (COPD) in the UK primary care setting. METHODS A retrospective cohort of newly diagnosed COPD patients was identified in the Clinical Practice Research Datalink (CPRD) from 1/1/2008 until 31/12/2009. Maintenance therapy prescribed within the first 3 months o...

in the third season excavation of lama cemetery (chal shahin lama), a cylindrical seal with inscription was found and because of its significance, it was introduced, compared and analyzed. existence of this seal indicates the continuation of nomadic practices of the people of this cemetery in spite of change of material culture (for example, ceramic). the seal of lama and its grave reflect the ...

OBJECTIVE This study aimed to investigate whether perioperative inhalations of long-acting beta-agonists (LABAs) or long-acting muscarinic antagonists (LAMAs) might decrease the incidence of postoperative complications in lung cancer patients with chronic obstructive pulmonary disease (COPD). METHODS We retrospectively analyzed 108 patients with COPD who underwent pulmonary resections for pri...

With Software Defined Networking (SDN), IP multicast becomes promising again. For IPTV applications over SDN, existing works would not scale well since they are based on per-source trees. As control-plane in SDN is logically centralized, constructing multiple shared trees is more feasible than that in traditional IP networks. Thus, in this work, we present a locality-aware multicast approach (L...

Bronchodilators are the cornerstone of the treatment of chronic obstructive pulmonary disease (COPD). In particular, the most commonly used drugs are inhaled long-acting agents, including long-acting β 2 -adrenergic agonists (LABAs) and long-acting muscarinic receptor antagonists (LAMAs). The combination of a LABA with a LAMA, i.e. of mole cules characterized by different mechanisms of action, ...

Several fixed-dose combinations (FDCs) of long-acting bronchodilators (a long-acting muscarinic antagonist [LAMA] plus a long-acting β2-agonist [LABA]) are available for the treatment of COPD. Studies of these FDCs have demonstrated substantial improvements in lung function (forced expiratory volume in 1 second) in comparison with their respective constituent monocomponents. Improvements in pat...

INTRODUCTION The once-daily long-acting muscarinic antagonist (LAMA) tiotropium and once-daily long-acting β2-agonist (LABA) olodaterol have been studied as a once-daily fixed-dose combination (FDC) in patients with chronic obstructive pulmonary disease (COPD). Two large, 52-week, double-blind, parallel-group studies in patients with moderate-very severe COPD demonstrated that tiotropium + olod...

Bronchodilators are the cornerstone of the treatment of chronic obstructive pulmonary disease (COPD). In particular, the most commonly used drugs are inhaled long-acting agents, including long-acting β2-adrenergic agonists (LABAs) and long-acting muscarinic receptor antagonists (LAMAs). The combination of a LABA with a LAMA, i.e. of molecules characterized by different mechanisms of action, res...

THIS PAPER WILL PRESENT some rhetorical and discursive elements in oral versions of the history of the Kālacakratantra as currently presented by the Fourteenth Dalai Lama. Focusing on the definition of the Kālacakra’s “word of the Buddha” (buddha vacana), the paper will show how the Fourteenth Dalai Lama constructs an innovative version in his teachings, manifesting the relations between the es...

In this paper, we will propose a MAC with two versions, which is called LAMA. The proposal MAC has the input size of 128 bits and 256 bits in the versions 1, 2 respectively, and output size of 128 bits. There have not been found a attack better than the exhaustive search attack for the MAC, and it has a fast implementations in about 5 / cycles byte in the both versions.