The mucosa of the gastrointestinal tract is presumably an important reservoir for human immunodeficiency virus type 1 (HIV-1), but the level of virus-expressing cells within the mucosa of infected patients is not known. To study this issue, we identified HIV-1 mRNA-expressing (positive) mononuclear cells by in situ hybridization in specimens of esophageal mucosa from eight patients with acquire...

Secretory IgA plays a crucial role in the host immune response as a first line of defense. A recent demonstration of in situ IgA class switching in intestinal lamina propria provided an opportunity to reconsider the model for the homing of IgA-committed B cells characterized by distinctive trafficking patterns to effector sites. Those effector sites depend on the organized mucosa-associated lym...

Abstract Background Melanosis of the bladder is a rare condition characterized by multifocal, diffuse melanin pigmentation urothelial mucosa or lamina propria without any proliferation melanocytes. Less than 25 cases have been reported so far which only four patients had concurrent carcinoma. Case presentation We are reporting case melanosis in 58-year-old female associated with pTaG1 transitio...

The concentration of IgG and IgA was measured in the supernatants of peripheral blood mononuclear cells and of cells harvested from the intestinal lamina propria, which were cultured in vitro in the presence or absence of mitogens. The lamina propria mononuclear cells were harvested by collagenase digestion of macroscopically normal mucosa from 10 fresh surgical resections for carcinoma. Secret...

The intestine of adult indigenous goat of Assam (Capra hircus) was studied by scanning electron microscopy (SEM) for elucidating the morphology of intestinal mucosa as well as the morphology of gutassociated lymphoid tissue including Peyer’s patches (PP) and solitary lymphoid nodule. SEM of intestines revealed the presence of villi in the small intestinal mucosa. Goblet cells were noticed as wh...

BACKGROUND Proteoglycans, consisting of glycosaminoglycan (GAG) side chains covalently linked to a protein core, are a major component of the extracellular matrix of the intestinal lamina propria. AIMS This study investigated the effects of lamina propria T cell activation on the proteoglycan component of the matrix. METHODS The high degree of sulphation of GAGs means that they are polyanio...

introduction: cell transplantation is one of the main strategies for spinal cord injury repair. as oecs of the olfactory mucosa can be obtained by simple biopsy in all individuals without affecting their smell sensation, oecs considered as a promising candidate for autologous transplantation in the nervous system injury, especially for spinal cord repair. thereby in the current study oecs were ...

The lymphocytes of epithelial and lamina proprial compartments of the intestine are phenotypically and functionally distinct and serve a wide range of functions in the intestinal mucosa like regulating intestinal homeostasis, maintaining epithelial barrier function as well as regulating adaptive and innate immune responses. To analyze the role of these cells in different disease states, it is n...

The olfactory mucosa, located in the nasal cavity, is in charge of detecting odours. It is also the only nervous tissue that is exposed to the external environment and easily accessible in every living individual. As a result, this tissue is unique for anyone aiming to identify molecular anomalies in the pathological brain or isolate adult stem cells for cell therapy. Molecular abnormalities in...