Intravesical immunotherapy with bacille-Calmette-Guerin (BCG) is indicated in the treatment of high-risk and intermediate-risk non-muscle invasive bladder cancer (NMIBC). Our goal is to describe the various disease states following induction and maintenance BCG and to describe contemporary treatment options and the current and projected clinical trial landscape for patients who recur following ...

Landscape ecology, if not ecology in general, is largely founded on the notion that environmental patterns strongly influence ecological processes [1, 2]. The habitats in which organisms live, for example, are spatially structured at a number of scales, and these patterns interact with organism perception and behavior to drive the higher level processes of population dynamics and community stru...

Although lawn care and landscape maintenance professionals appear increasingly willing to use Integrated Pest Management (IPM) strategies and adopt nonchemical pest management alternatives into management practices, the opinions of landscape management professionals have not been assessed regarding anticipated influences of increased use of insectand disease-resistant ornamental plants on groun...

The maintenance of recombination is among the most important unsolved problems of evolutionary biology. The Hill-Robertson effect, which states that the interaction between genetic drift and selection generates unfavorable linkage dise-quilibria (hence favoring recombination), offers one of the most promising hypotheses to solve this problem. In particular,it has been argued that th...

0

Many organizational theories are not sanguine over the chances of organizations to adapt and evolve, even if they should learn from the past through memory. Innovative search in the adaptive biology tradition leads quickly to dead ends. However, memory is useful for rendering innovative search more efficient. The concept from evolutionary biology of neutrality and drift along neutral pathways i...