Langerhans cell histiocytosis (LCH) is a rare disorder characterised by increased production of Langerhans-type histiocytes. It more common in the pediatric age group with predilection for osseous involvement, though any organ may be involved. A 10-year male child was brought to neurosurgical clinic slow growing painful tender mass on head. Initial attempt biopsy lesion failed due excessive ble...

Tumor lesion of the orbit is found in clinic various oncohematological diseases children. Untimely referral such patients to an oncologist delays timing necessary treatment, thereby worsening prognosis disease. The literature review presents features clinical manifestations orbital pathology children at onset acute myeloid leukemia, sarcoma, lymphoma, Langerhans cell and non-Langerhans histiocy...

Langerhans cell histiocytosis is a disease primarily affects the bone. More than 50 percent of the disease occurs between the age of 1 and 15. We reported a case of a 2 year old boy who presented with a gluteal mass. Radiographic imaging showed an osteolytic lesion suspicious of malignancy. However, the histological diagnosis was Langerhans cell histiocytosis.

We describe a 2 ½ year old boy presenting with fever, abdominal pain and splinter haemorrhages of the nails. On further examination there were signs of pneumonia with pleural effusion. This was treated with mini-thoracotomy, drainage and intravenous antibiotics. Further diagnostic workup for underlying causes showed diffuse cystic lung disease, suggestive of Langerhans cell histiocytosis. This ...

We report Langerhans cell histiocytosis involving the sphenoid sinus and extending to the orbital apex. MR and CT imaging, particularly with contrast, both were helpful in defining the extent of the lesion before treatment. MR was a useful examination for follow-up after treatment. Langerhans cell histiocytosis should be considered in the differential diagnosis of lesions of this region in the ...

BACKGROUND Langerhans cell histiocytosis is a sporadic disease caused by an uncontrolled pathogenic clonal proliferation of dendritic cells that have Langerhans cell characteristics. New treatment protocols provided by the HISTSOC-LCH-III (NCT00276757) trial show an improvement in the survival of children with langerhans cell histiocytosis. CASE PRESENTATION We report a case of Langerhans cel...

Vertebral Langerhans cell histiocytosis, formerly called Histiocytosis X, is rarely seen in adults: a systematic non-quantitative review of the literature yielded only 27 cases. Vertebra plana is often associated in children, but this is not a feature in the adult population. The authors report the case of a 29-year-old woman with a two-month history of lumbar pain. Osteolysis of the right pedi...

conclusions a high index of suspicion is required for the early diagnosis and prompt treatment of patients with osseous tuberculosis. given the high prevalence of tuberculosis in developing countries, tuberculosis should be considered in the differential diagnosis of multifocal lytic lesions and vertebra plana, especially in children. introduction multifocal skeletal tuberculosis is a rare cond...

Pulmonary Langerhans cell histiocytosis (PLCH) is a rare interstitial lung disease seen as part of multisystem Langerhans cell histiocytosis, or as an isolated form of the disease. The majority of cases of the latter are seen in adults and associated with cigarette smoking, which probably plays a central etiologic role. Although the mechanisms leading to the development of isolated PLCH are unc...