Three novel phenylpropanoid glycosides 2, 5, 6 were isolated from water extract of Tabebuia avellanedae, together with three known phenylpropanoid glycosides 1, 3, 4. All compounds were identified on the basis of spectroscopic analysis and chemical methods and, for known compounds, by comparison with published data. All isolated compounds showed strong antioxidant activity in the DPPH assay, an...

Neotropical parrots forage for various food items such as seeds, fruit pulp, flowers, young leaves, and even arthropods. While foraging, many species wander over large areas that include both open and closed habitats. In this study, I examined parrot foraging activity during a brief synchronous and massive flowering in August 1998 in a tecoma savanna (dominated by Tabebuia aurea) in the souther...

Tabebuia species (Bignoniaceae) have long been used in folk medicine as anti-inflammatory, antirheumatic, antimicrobial, and antitumor. The aim of this study was to investigate if aqueous extract from the leaves (AEL) of Tabebuia roseoalba (Ridl.) Sandwith, Bignoniaceae, and its constituents could be useful to decrease serum uric acid levels and restrain the gout inflammatory process. HPLC anal...

Tissue and organ regeneration, unlike development, involves an injury that in postembryonic animals triggers inflammation followed by resolution. How inflammation affects epimorphic regeneration is largely uninvestigated. Here we examine inflammation and its resolution in Xenopus laevis hindlimb regeneration, which declines during larval development. During the first 5 days postamputation, both...

It is my great pleasure to announce the launch of new alliance between our journal, Inflammation and Regeneration, and an international publisher, BioMed Central. Inflammation and Regeneration is the official journal of the Japanese Society of Inflammation and Regeneration. Inflammation and Regeneration provides a forum which covers a wide range of scientific topics in the research field of inf...

UNLABELLED Beta-lapachone (beta-Lp) derived from the Lapacho tree is a potentially novel anticancer agent currently under clinical trials. Previous studies suggested that redox activation of beta-Lp catalyzed by NAD(P)H quinone oxidoreductase 1 (NQO1) accounted for its killing of cancer cells. However, the exact mechanisms of this effect remain largely unknown. Using chemiluminescence and ele...

Blood platelets have long been recognised to bring about primary haemostasis with deficiencies in platelet production and function manifesting in bleeding while upregulated function favourises arterial thrombosis. Yet increasing evidence indicates that platelets fulfil a much wider role in health and disease. First, they store and release a wide range of biologically active substances including...

プロスタノイ ドは通常は細胞内に貯蔵されてお らず,細 胞内で必要 に応 じて合成,放 出され,そ の局所で多彩な作用 を発揮 し,生 体 のホメオスタ シスの維持 に関わる重要なオータコイドである. なかでも,生 体内において もっとも豊富に存在す るプ ロスタノイ ドであ るプロスタ グラ ンジン (PG)E2の 生理活性は血管拡張,胃 液分泌抑制,子 宮収縮,気 管支拡張,発 熱や発痛,炎 症反応など 多岐にわたっている.PGE2生 合成経路 はつぎの ような複数の酵素を介 した反応系で説明されてい る.す なわち,細 胞が生理的,病 理的なさまざま な刺激を受 けると,ホ スホ リパーゼA2(PLA2)に より生体膜 リン脂質からアラキドン酸が遊離され たあと,こ のアラキドン酸がシクロオキシゲナー ゼ(COX)に よりPGH,に 変換 される.さ らに,こ のPGH2がPG...

Summary Bone healing involves complex biological pathways and interactions among various cell types and microenvironments. Among them, the monocyte-macrophage-osteoclast line-age and the mesenchymal stem cell-osteoblast lineage are critical, in addition to an initial inflammatory microenvironment. These cellular interactions induce the necessary inflammatory milieu and provide the cells for bon...

Chronic liver disease is a progressive deterioration of hepatic functions and continuous process inflammation, destruction, regeneration parenchyma, resulting in fibrosis cirrhosis [...]