BACKGROUND Octreotide long-acting repeatable (LAR) is approved in the United States for the management of carcinoid syndromes among patients with neuroendocrine tumors (NET). The objective of our study is to evaluate the impact of octreotide LAR on overall survival (OS), as it has not been established. METHODS NET patients of 65 years and older diagnosed between January 1999 and December 2009...

OBJECTIVE This study compares 3 cohorts of patients with schizophrenia before, during, and after initiating treatment with fluphenazine decanoate (FD), haloperidol decanoate (HD), or long-acting injectable risperidone (LAR). METHODS Administrative data are analyzed from California Medicaid (Medi-Cal) beneficiaries with schizophrenia who initiated FD, HD, or LAR treatment. Patients were requir...

Mesenchymal stem cells (MSCs) are multipotent adult stem cells that can differentiate into a variety of mesodermal-lineage cells. MSCs have significant potential in tissue engineering and therapeutic applications; however, the low differentiation and proliferation efficiencies of these cells in the laboratory are fundamental obstacles to their therapeutic use, mainly owing to the lack of inform...

The location-aided routing scheme 1 (LAR-1) and probabilistic algorithms were combined together into a new algorithm for route discovery in mobile ad hoc networks (MANETs) called (LAR-1P) [1]. Simulation results demonstrated that, on network scale, for a uniform random node distribution and for a specific simulation setup (time); the LAR-1P algorithm reduces the number of retransmissions as com...

In this paper, we study the performance of two important types of decode–and–forward (DF) relaying schemes proposed for cooperative diversity (CD) systems, namely, cooperative maximum–ratio combining (C–MRC) and link adaptive regeneration (LAR). In particular, we provide a unified framework for the error rate performance analysis of C–MRC, LAR–αinst, and LAR–α DF schemes for multi–branch CD sys...

Drosophila and leech models of nervous system development demonstrate that protein tyrosine phosphatase (PTP) receptors regulate developmental neurite outgrowth. Whether PTP receptors regulate neurite outgrowth in adult systems or in regenerative states remains unknown. The leukocyte common antigen-related (LAR) receptor is known to be present in rodent dorsal root ganglion (DRG) neurons; there...

BACKGROUND Long-acting sandostatin (S-LAR; octreotide acetate) is well tolerated and effective for symptom control and possibly disease control in gastroenteropancreatic neuroendocrine tumors (GEP-NETs). We undertook a retrospective analysis to study the efficacy and tolerability of higher doses (more than 20-30 mg/month) of S-LAR in GEP-NETs. PATIENTS AND METHODS With IRB approval, charts of...

OBJECTIVE Octreotide is used to treat patients with neuroendocrine tumors. Previous reports show that octreotide long-acting repeatable (LAR) dose and patient body weight affect nadir plasma octreotide levels (approximately 1250, 2500, 5000, and 11,000 pg/mL for LAR doses of 10, 20, 30 and 60 mg/mo). However, plasma octreotide levels have decreased over time in patients receiving these doses of...

Location-Aided Routing (LAR) 14] algorithm is an approach to utilize location information for mobile hosts, with the goal of decreasing routing-related overhead in mobile ad hoc networks. A number of optimizations are possible to improve performance of the basic LAR protocols. This paper mainly focuses how the basic operation of LAR can be improved by applying those optimization schemes.