AIM This study aims to investigate the possible role of H. pylori as a cause of laryngeal squamous cell carcinoma. METHOD This controlled study was performed with 31 consecutive laryngeal cancer and 28 cancer-free patients who underwent direct laryngoscopy and biopsy of laryngeal lesions. To document the previous H. pylori infection, serological analysis of the antibody titers was done. Immun...

4. Lewis JE, Olsen KD, Sebo TJ. Spindle cell carcinoma of the larynx: Review of 26 cases including DNA contentandimmunohistochemistry Hum Pathol 1997; 28: 664-673. 5. Lane N. Pseudosarcoma (polypoid sarcoma-like masses) associated with squamous cell carcinoma of the mouth, tauces and larynx. Report ot10 cases. Cancer 1957; 10:19-41. 6. Ackerman LV. Verrucous carcinoma ofthe oral cavity Surgery ...

Ki-67 is one of the most useful markers to evaluate cell proliferative activity and has been widely used in tumor treatment and research. However, its role in human laryngeal carcinoma remains poorly defined. The aim of the present study was to investigate the expression of Ki-67 in human laryngeal squamous carcinoma and the effect of Ki-67 gene silencing by small interfering (si)RNA on the pro...

OBJECTIVE To survey the role of Helicobacter pylori at the tissue level as a cause of squamous cell carcinoma of the larynx. DESIGN A case-control study. SETTING In an Otolaryngology Ward at an academic university. SUBJECTS Patients with laryngeal cancer as cases and patients with benign laryngeal lesion as controls. MAIN OUTCOME MEASURE In all subjects, specimens of laryngeal tissue we...

background and objective: cutaneous cytology is the study of scraping or smears obtained from skin lesions. although not commonly employed, cutaneous cytology has been a useful tool for clinicians due to simplified procedures and high sensitivity and specificity of presurgical clinical diagnosis of common types of skin tumors. this investigation was conducted to study usefulness of cutaneous cy...

background: invasive squamous cell carcinoma of the vulva is primarily a disease of postmenopausal women and thus is rarely associated with pregnancy. case: we have reported on a young woman under 40 years old with vulvar carcinoma, which occurred during the pregnancy but optimal treatment was delayed to the postpartum period. this 37-year-old woman was diagnosed with 3x3 cm vulvar lesion, 2 we...

background and objectives: squamous cell carcinoma of the tongue (sccot) is the most common malignant neoplasm in oral cavity. at the time of the diagnosis of sccot regional metastases with a high mortality rate are common, which is due to the extensive lymphatic system drainage of the tongue. although the level of healthcare has significantly improved, the survival rate is still low with an un...

Although the association and clinical significance of human papillomavirus (HPV) infections with a subset of head and neck cancers, particularly for oropharyngeal carcinoma, has recently been well documented, the involvement of HPV in laryngeal cancer has been inadequately evaluated. Herein we review the currently known associations of HPV infections in diseases of the larynx and their potentia...

Fanconi anemia (FA) associated genes [FANCA, -B, -C, FANCD1(BRCA2), -D2, -E, -F, -G, -I, -L, -M, FANCN (PALB2), FANCJ(BRIP1) and FA-linked BRCA1] encode proteins of DNA damage response pathways mutated in FA patients. FA is characterized by congenital malformations, chromosomal instability and high cancer susceptibility. FA patients have a 500-700 times higher risk of head and neck squamous cel...

BACKGROUND The clinical relevance of the carbohydrate antigen Sialyl Lewis a (SLea) as a serum tumor marker in diagnosis and follow-up treatment is unquestioned in a broad spectra of human carcinomas. Overexpression of this antigen is combined with poor prognosis and malignant relapse. The aim of our study was the systematic investigation of SLea expression in squamous cell carcinoma of the lar...