The multisubunit homotypic fusion and vacuole protein sorting (HOPS) membrane-tethering complex is required for late endosome-lysosome and autophagosome-lysosome fusion in mammals. We have determined the crystal structure of the human HOPS subunit Vps33A, confirming its identity as a Sec1/Munc18 family member. We show that HOPS subunit Vps16 recruits Vps33A to the human HOPS complex and that re...

The four new compounds CsTmCoS3, CsYbCoS3, CsHoCoSe3, and CsYbCoSe3 have been synthesized at 1123 K. These black-colored isostructural compounds crystallize in the KZrCuS3 structure type with four formula units in space group Cmcm of the orthorhombic system. The structure of these compounds is composed of 2 [LnCoQ3 ] layers separated by Cs atoms. Because there are no Q Q bonds, the formal oxida...

In Drosophila circadian rhythms persist in constant darkness (DD). The small ventral Lateral Neurons (s-LNv) mainly control the behavioral circadian rhythm in consortium with the large ventral Lateral Neurons (l-LNv) and dorsal Lateral Neurons (LNd). It is believed that the molecular oscillations of clock genes are the source of this persistent behavior. Indeed the s-LNv, LNd, Dorsal Neurons (D...

For mate-searching species, the learnedmate recognition (LMR) hypothesis assumes that sexual harassment favours signal variation among females, which exploits the receiver ability of males. Themodel predicts that coevolving males have responded to the female sexual foil by learning to recognize female variants as potential mates. I translate the LMR hypothesis into the language of signal detect...

Psychophysical functions for perceived roughness, relating ln (magnitude estimate of roughness) to ln (groove width), were obtained for blind and sighted participants in virtual reality using the PHANToM force feedback device. The stimuli were sinusoidal surfaces with groove widths between 0.675 mm and 20.700 mm. Group functions showed a similar nonlinearity to those obtained in physical realit...

In an effort to realize wireless Internet telephony and multimedia streaming in a highly mobile environment a testbed emulating a wireless Internet has been built. This would allow setting up multi-media calls between IP mobiles and integration between IP and PSTN end-points in a wireless environment. Different functionalities and components involved with the wireless Internet streaming multime...

On the semantics of determiners in a rich type-theoretical framework The variation of word meaning according to the context led us to enrich the type system of our syntactical and semantic analyser of French based on categorial grammars and Montague semantics (or lambda-DRT). The main advantage of a deep semantic analyse is too represent meaning by logical formulae that can be easily used e.g. ...

An end-grafted flexible polymer chain in three-dimensional space between two pistons undergoes an abrupt transition from a confined coil to a flowerlike conformation when the number of monomers in the chain, N, reaches a critical value. In two-dimensional (2D) geometry, excluded-volume interactions between monomers of a chain confined inside a strip of finite length 2L transform the coil confor...

We present quadratic convergent algorithms for the computation of standard interval functions like √ , ln, arctan in a multiple-precision interval arithmetic. These algorithms depend on elliptic integrals of the first and second kind and the method of arithmetic and geometric means. Представлены квадратично сходящиеся алгоритмы для вычисления стан-дартных интервальных функций, таких как √ , ln,...

In common parlance, creativity is understood as an extraordinary ability, with which only few are gifted. However, the book ‘An Interaction: Creativity, Cognition and Knowledge’ emphasizes the idea that creativity can be better understood as common cognitive phenomena. It poses a challenge to our understanding of the knowledge and performance of our cognitive systems. Drawing on the theoretical...