Background: Relationship between abnormal posture and QOL of Parkinson's disease is not clear. Objectives: To clarify the association between quality of life (QOL) and abnormal posture in patients with Parkinson’s disease (PD) and examine which QOL dimensions are involved. Methods: This study retrospectively examined PD patients (n = 57) who had undergone outpatient rehabilitation between Janua...

Effective monitoring of bulbar disease progression in persons with amyotrophic lateral sclerosis (ALS) requires rapid, objective, automatic assessment of speech loss. The purpose of this work was to identify acoustic features that aid in predicting intelligibility loss and speaking rate decline in individuals with ALS. Features were derived from statistics of the first (F1) and second (F2) form...

Glycine‐rich regions form intrinsically unstructured domains within RNA‐binding proteins. Although they lack a defined structure when alone in solution, these domains can form more defined structural elements when interacting with other proteins or with RNA. TDP‐43 and FUS are RNA binding proteins with glycine‐rich domains that form abnormal aggregates in amyotrophic lateral sclerosis (ALS) and...

[1] For iterative calculations of synthetic seismograms with limited computer resources, a fast and accurate modeling method is needed. Axisymmetric modeling has often been used in global seismology to restrict computational time and storage. This approach can correctly model 3-D geometrical spreading effects with computational times comparable to 2-D methods, but cannot treat asymmetric struct...

This open-access article is published and distributed under the Creative Commons Attribution NonCommercial No Derivatives License (http://creativecommons.org/licenses/by-nc-nd/3.0/), which permits the noncommercial use, distribution, and reproduction of the article in any medium, provided the original author and source are credited. You may not alter, transform, or build upon this article witho...

This open‐access article is published and distributed under the Creative Commons Attribution ‐ NonCommercial ‐ No Derivatives License (http://creativecommons.org/licenses/by‐nc‐nd/3.0/), which permits the noncommercial use, distribution, and reproduction of the article in any medium, provided the original author and source are credited. You may not alter, transform, or build upon this article w...

Amyotrophic Lateral Sclerosis (ALS) is a progressively debilitating neuro-degenerative condition that occurs in adulthood and targets the motor neurons. Social support is crucial to the well-being and quality of life of people with unpredictable and incurable diseases such as ALS. Members of the PatientsLikeMe (PLM) ALS online support community share social support but

The classical form of amyotrophic lateral sclerosis (ALS) or Charcot's disease contains both familial and sporadic cases. The familial form has been extensively reviewed by Faveret (1959), Haberlandt (1964), and Becker (1966). Sporadic cases present the same clinical features. In addition, there is a form of the disease encountered in the native inhabitants of Guam and Japan. It displays severa...

Introduction: Investigators have drawn nasolabial angle using different soft tissue landmarks. This has created confusion among the orthodontic students and clinicians regarding its construction. Objective: To evaluate two commonly used methods of constructing the nasolabial angle in order to establish a single reproducible method. Materials & Method: Lateral cephalograms of 120 patients underg...