BACKGROUND Uterine leiomyoma is the most common benign tumor in women and is thought to arise from the clonal expansion of a single myometrial smooth muscle cell transformed by a cellular insult. Leiomyomas cause a variety of symptoms, including abnormal uterine bleeding, pelvic pain, bladder or bowel dysfunction, and recurrent pregnancy loss, and are the most common indication for hysterectomy...

OBJECTIVE To elucidate the direct effects of gonadotropin-releasing hormone agonist (GnRHa) on the growth of human uterine leiomyoma cells, cell proliferation and apoptosis in cultured leiomyoma cells treated with GnRHa were investigated. METHODS Isolated leiomyoma cells were subcultured in DMEM supplemented with 10% FBS for 5 days and stepped down to serum-free conditions for an additional 6...

We report two rare cases of female patients presenting with oesophageal leiomyoma associated with oesophageal diverticulum, both of whom were surgically managed. Oesophageal leiomyoma and oesophageal diverticulum are uncommon as separate entities and rare as combined disease presentation. Clinicians need to be aware of the rare combination of the two entities and need to be able to exclude the ...

Atypical bladder leiomyoma is a rare bladder tumor that is difficult to be correctly identified by imaging techniques or cystoscopy. We present the imaging characteristics of an atypical bladder leiomyoma and review the relative literature, with the aim of enhancing awareness of the differential diagnosis of bladder leiomyoma, to avoid and reduce misdiagnosis. The imaging characteristics of the...

Epithelioid leiomyoma of the vagina is extremely rare. Smooth muscle tumors of the vagina usually present with a submucosal growth pattern or a pedunculated growth pattern from the anterior vaginal wall into the vaginal cavity. Here we report a case of a 43-year-old woman with a solid epithelioid leiomyoma and a palpable mass in the pouch of Douglas. Transvaginal biopsy and angiography showed t...

Leiomyoma in the female genital tract is a common benign tumor of the uterus, followed by cervix, round ligament and inguinal ligament. Vaginal leiomyoma is a rare entity with only about 300 reported cases. Here, we report a case of a vaginal leiomyoma in a 22 year old nullipara who presented with dyspareunia and infertility. Vaginal examination revealed a mass in the anterior vaginal wall. MRI...

uterine leiomyoma is the most common benign tumor of genital tract. the etiology of myomas is unknown. leiomyoma shows a broad spectrum of radiographic appearances depending on the number, size, and location of the tumor. the diagnostic method for uterine leiomyomas is based primarily on the clinical situation. despite of the varied diagnostic options such as; transvaginal sonography, sonohyste...

Benign metastasizing leiomyoma is very rare and usually occurs in women who undergo hysterectomy and myomectomy for uterine leiomyoma. This is a benign spindle-shaped smooth muscle cell tumor pathologically but metastasizes to the extrauterine organs. Lungs are the most common site of metastasis. We observed three cases of pulmonary benign metastasizing leiomyoma.

Leiomyoma is an uncommon tumor of the kidney. The authors report a rare case of renal leiomyoma in a 39-year-old male patient who presented with a right flank mass. Laparoscopic nephrectomy was performed. The histopathology and immunohistochemistry confirm the diagnosis of renal leiomyoma. The review of literature in the clinicoradiopathological correlation was illustrated.

BACKGROUND Uterine leiomyomas (fibroids) are the most common gynaecological benign tumors in premenopausal women. Evidences support the role of oxidative stress in the development of uterine leiomyoma. We have analysed oxidative stress markers (thiols, advanced oxidized protein products (AOPP), protein carbonyls and nitrates/nitrites) in preoperative sera from women with histologically proven u...