Leptomeningeal metastasis (LM) of uterine cervical cancer is extremely rare. A 54-year-old woman with uterine cervical cancer treated with surgery and radiotherapy developed LM manifesting as ptosis 17 years later. Although rare, LM should be considered in patients with a history of uterine cervical cancer presenting with cranial nerve symptoms.

INTRODUCTION To compare the diagnostic accuracy of contrast-enhanced 3D(dimensional) T1-weighted sampling perfection with application-optimized contrasts by using different flip angle evolutions (T1-SPACE), 2D fluid attenuated inversion recovery (FLAIR) images and 2D contrast-enhanced T1-weighted image in detection of leptomeningeal metastasis except for invasive procedures such as a CSF tappin...

Internal auditory canal (IAC) metastasis due to leptomeningeal carcinomatosis (LMC) from gastric cancer (GC) has rarely been reported. Early manifestation of symptoms, such as hearing loss, vertigo and facial paralysis, in cases of IAC metastasis due to LMC may facilitate the early detection of brain metastasis. To the best of our knowledge, the present study is the first to report IAC metastas...

Dissemination of tumor to the leptomeninges and cerebrospinal fluid represents a common pattern of metastasis for many cancers; however, few chemotherapeutic agents are available for intrathecal (i.t.) use and treatment results are often poor. We studied the neurotoxicity and pharmacokinetics of i.t. 4-hydroperoxycyclophosphamide (4-HC) in the rabbit and the activity of i.t. 4-HC in a VX2 rabbi...

To cite: McCusker MW, Looby S. BMJ Case Rep Published online: [please include Day Month Year] doi:10.1136/bcr-2014203958 DESCRIPTION A 54-year-old man presented with a 7-week history of morning headaches and vomiting. He described dizziness and balance problems during the preceding 6 months. Clinical examination revealed bilateral optic disc blurring and bilateral lower limb hyper-reflexia. Con...

PURPOSE To evaluate the clinical and MR findings of metastatic lesions involving the cerebellopontine angle (CPA), which may be useful in differentiating them from the more commonly occurring benign CPA lesions. METHODS Clinical and MR findings of 14 patients with clinical/radiologic (seven) or pathologic (seven) diagnoses of CPA metastasis were retrospectively reviewed. RESULTS Useful clin...

Metastases to the spine resulting in spinal neuropathy occur commonly _ The vast majority involve the vertebrae and the epidural spaces. Intradural metastases, either extraor intra-medullary arising from a primary lesion outside of the central nervous system are seldom encountered. Another rare form of metastatic disease to the spinal central nervous system is leptomeningeal carcinomatosis. Thi...