We have reviewed the neurological complications not directly attributable to leukaemic infiltration in a group of 438 children with leukaemia or lymphoma. 61 children had one or more complications due chiefly to bleeding, infection, or drug toxicity. Early death from intracranial haemorrhage occurred in 1% of children with lymphoblastic leukaemia and 7% of children with myeloblastic leukaemia. ...

Twenty-four consecutive deaths from a total of 70 children receiving treatment for acute lymphoblastic leukaemia (ALL) have been reviewed. An attempt has been made to ascribe the cause of death to either infection, haemorrhage, the leukaemia itself, or a combination of these factors. No child was free of infection at death. Infection, with or without haemorrhage, was responsible for the deaths ...

Survival after acute paediatric (0-14 years), adolescent (15-19 years) and young adult (20-39 years) leukaemia has improved substantially over the last five decades, particularly for acute lymphoblastic leukaemia (ALL) and acute promyelocytic leukaemia. This progress represents one of the most successful achievements in the history of medicine and has been attributed to the development of effec...

The incidence of acute biphenotypic leukaemia has ranged from less than 1% to almost 50% in various reports in the literature. This wide variability may be attributed to a number of reasons including lack of consistent diagnostic criteria, use of various panels of antibodies, and the failure to recognize the lack of lineage specificity of some of the antibodies used. The morphology, cytochemist...

agreements regarding the origin of monocytes, and from the use of different names by various authorities to indicate this condition. At the present time, the monocytes are regarded as an independent line of cells, distinct from granulocytes and lymphocytes, and monocytic leukaemia is accepted as a clinical and haematological entity, though a considerable degree of disagreement in nomenclature s...

BACKGROUND In 2002, a poster alerted the French health authorities to the possibility that the risk of childhood leukaemia might be increased by hepatitis B vaccination. Elucidating the role of vaccination in the aetiology of childhood acute leukaemia (AL) was therefore included in the objectives of an ongoing national study. METHODS The ESCALE study was a French national population-based cas...

OBJECTIVE To test the hypothesis of an association between neonatal intramuscular vitamin K and childhood leukaemia and other cancers. DESIGN Population based case-control study with data abstracted from hospital records. SETTING Scotland. SUBJECTS Children aged 0-14 years resident in Scotland from 1991-4 and diagnosed with leukaemia (150), lymphomas (46), central nervous system tumours (...

Four patients in whom a diagnosis of acute monocytic leukaemia (M5) was subsequently made presented with extramedullary disease clinically resembling lymphoma. In all patients histological sections were initially misinterpreted as showing malignant lymphoma or anaplastic carcinoma. The diagnosis of M5 leukaemia was subsequently made on the basis of morphological and cytochemical studies of peri...

Orbital or subconjunctival infiltration occurs frequently in acute and chronic lymphatic leukaemia, but only rarely in myelogenous leukaemia (Chatterjee and Sen, I 960). Chloroma, an atypical form of myeloblastic leukaemia, often manifests itself as a localized mass in the orbital periosteum, and the proptosis produced in such cases may be the first sign of the disease (Goodman and Iverson, I94...

Secondary involvement of female genitourinary system [1, 2] is more common in lymphoma than leukaemia [3, 4]. In leukaemia, acute myeloid leukaemia (AML) is known to have extra medullary involvement (chloroma, granulocytic sarcoma, etc.) [5, 6]. In case of acute lymphoblastic leukaemia (ALL), except for CNS and testis other extra medullary sites are rarely involved [7, 8]. Amongst genitourinary...