Background: Opium addiction alters immune responses to stresses such as an injury due to changing the secretion of cytokines. The present study assessed the effect of opium addiction on the cytokines [tumor necrosis factor α (TNFα), interferon-γ (IFN-γ), interleukin-4 (IL-4), and IL-10] before and after laparotomy. Methods: Male rats were randomly divided into control and opium addicted (n = 20...

Abstract Objective: Interferon-γ (IFN-γ) is a key cytokine regulating the development of atherosclerosis, but little known regarding phenotype and regulation T cells producing IFN-γ in plaques. Methods: To identify characterize IFN-γ-producing we utilized IFN-γ-YFP Nur77-GFP reporter mice crossed onto an atherosclerotic background (Apoe−/−IFN-γ YFP/YFP; Apoe−/−Nur77GFP/wt), adoptive transfer tr...

The administration of interferon has improved the antiviral and immunomodulatory abilities piglets, which is conductive to prevention potential diseases or delay appearance clinical symptoms. This study aimed evaluate effects from recombinant interferon-alpha (IFN-α) on daily care piglets. results were compared a Chinese herbal drug that was shown increase serum levels. In addition, routes oral...

To explore the role of Toll-like receptors (TLRs) and interferon (IFN) in innate immunity against porcine epidemic diarrhea virus (PEDV), we detected expression TLR genes PEDV-infected IPEC-J2 cells by real-time PCR. We also level α (IFN-α) γ (IFN-γ) enzyme-linked immunosorbent assay (ELISA). Results showed that exhibited a clear pathological change after PEDV infection at 24 h. In addition, TL...

it is now well documented that interferon gamma (ifn-γ) is the indispensable cytokine for inducing protective immunity against experimental and human cutaneous leishmaniaisis. the importance of ifn-γ receptor (ifn-γr) has also been studied. in the present study, we made attempts to find out whether l. major infection is able to alter the expression of ifn-γr in vivo. in addition, we studied the...

Objective(s): The effects of PPAR-γ agonist alone and in combination with carvacrol and Zataria multiflora on inhaled paraquat (PQ) induced-systemic inflammation and oxidative stress were examined. Materials and Methods: Control group exposed to normal saline aerosol, one group exposed to 54 mg/m3 PQ aerosol and four groups exposed to PQ...

conclusions this study demonstrated the detection of hcv-specific ifn-γ responses in hcv antibody and rna negative individuals, with a tendency for hcv-specific ifn-γ responses to be associated with hcv exposure. the potential role of hcv-specific ifn-γ responses in those who remained hcv rna negative is of value for the development of novel hcv therapeutics. objectives in a cohort of hcv antib...

Background: Cutaneous leishmaniasis (CL) is a self-healing disease, but due to unknown causes, a few cases of CL could get a chronic or non-healing course. These cases of chronic and recurrent leishmaniasis are defined as non-healing. Objectives: Comparison of the production of interferon-γ (IFN-γ) and Leishmanin skin test (LST) between non-healing and healed patients of CL. Patients and ...

Background: In addition to humoral immunity associated with anti-desmoglein antibodies, cellular immunity and mediators including cytokines are involved in the pathogenesis of pemphigus vulgaris. In this study we evaluated the level of IL-2, IFN-γ, TNF-α, IL-4, and IL-10 in the sera of patients with pemphigus vulgaris before and after treatment.Methods: A total number of 71 new patients with pe...

Today, the use of oak as a replacement feed in poultry diets is well documented. However, oak contains polyphenol compounds (tannins) as antinutrient factors resulted in limited usage in the poultry rations. Generally, consumption of feeds containing tannin could affect gene expression level of immune system. Therefore, the aim of this study was to investigate the effect of different levels of ...