The present study reveals a simple isocratic RP-HPLC method for the simultaneous determination of dextromethorphan hydrobromide and levocetirizine dihydrochloride in a cough syrup. The separation of these compounds was achieved within 10 min on a Phenomenex (USA) C(18) analytical column, 250×4.0 mm i.d., using an isocratic mobile phase consisting of potassium dihydrogen phosphate buffer (pH 2.5...

Wells' syndrome (WS), or eosinophilic cellulitis, is an uncommon inflammatory dermatosis of unknown etiology that typically presents with pruritic cellulitis-like plaques on the extremities. Therefore, WS is often misdiagnosed as bacterial cellulitis due to its similarity in presentation. Here, we report two cases of WS that masqueraded as bacterial facial cellulitis. Under treatment with oral ...

Aim To evaluate the efficacy of antihistamines in reducing pruritus in psoriasis, 61 patients were randomized to be treated for 1 week with clemastine (n = 20), levocetirizine (n = 21) or placebo (n = 20). Material and methods All patients received the same routine antipsoriatic treatment. Itch intensity was assessed with VAS and the Itch Questionnaire, and hand movements during sleep were co...

Summary According to current guidelines, non-sedative H1-antihistamines (nsAH) are the first-line therapy of chronic spontaneous urticaria (CSU). But even up-dosed antihistamines (to four times the standard dose) produce symptom resolution in less than 50% of patients. Biomarkers that can predict the response to nsAH are still unknown. We carried out a prospective study and used discriminant an...

These highlights do not include all the information needed to use XYZAL safely and effectively. See full prescribing information for XYZAL. XYZAL (levocetirizine dihydrochloride) 5 mg tablets 2.5 mg/5 mL (0.5 mg/mL) oral solution Initial U.S. Approval: 1995 ---------------------------RECENT MAJOR CHANGES--------------------------Dosage and Administration (2) 01/2008 Dosage and Administration, A...

Many drugs are available to treat allergic condition. This review focused on why antihistaminics best choice for treatment of disorder especially rhinitis (AR). AR is a chronic inflammatory disease. can be detected by its characteristics nasal congestion, itching, sneezing, rhinorrhoea, pruritis, redness, tearing and itching eyes. very common increases day after day. Allergic not lethal but int...

BACKGROUND: Allergic rhinitis is an inflammatory disease with worldwide prevalence of 10-40%. Clinically, the condition manifests as nasal itching (pruritus), sneezing, rhinorrhea, congestion and itchy eyes. The second generation antihistamines are commonly used either as nasal sprays (azelastine) or orally (levocetirizine). Studies have demonstrated equal efficacy of azelastine and levocetiriz...