Aims—To assess A103 (melan-A) immunoreactivity in a range of ovarian sex cord stromal tumours and to evaluate it for the diVerential diagnosis of other neoplasms. Methods—ParaYn embedded tissue sections from 45 sex cord stromal tumours and 44 potential histological mimics were examined immunohistochemically using the antibody A103. The sex cord stromal group included 21 adult granulosa cell tum...

AIMS To assess A103 (melan-A) immunoreactivity in a range of ovarian sex cord stromal tumours and to evaluate it for the differential diagnosis of other neoplasms. METHODS Paraffin embedded tissue sections from 45 sex cord stromal tumours and 44 potential histological mimics were examined immunohistochemically using the antibody A103. The sex cord stromal group included 21 adult granulosa cel...

Sex-cord stromal tumours account for only about 6% of testicular neoplasms.' Leydig cell tumour is the commonest sub-type but other tissues that can be represented in varying amounts and degrees of differentiation include Sertoli, granulosa and theca-lutein elements. Testicular granulosa-cell tumour ofthe adult type is particularly uncommon. This report details a mixed sex-cord stromal tumour o...

BACKGROUND Ovarian sex cord stromal tumors are rare neoplasms as compared to epithelial tumors. No large study has been done in Pakistan to find out the frequencies of various sex cord stromal tumors and their clinicopathological behavior in our region. The purpose of our study was to determine the various histological patterns and clinical features of ovarian sex cord stromal tumors along with...

Leydig cell testicular tumors are very rare in children and cause isosexual precocious puberty. Palpable testicular mass or asymmetric testes are common findings on routine examination. We report on a 5-yr-old boy with a Leydig cell tumor of the testis presented with isosexual precocious puberty but no scrotal palpable mass. To our knowledge, this is the first reported Leydig cell tumor in a bo...

Sex cord tumor with annular tubules (SCTAT) is a highly rare type of ovarian sex cord-stromal (SCST), the diagnosis which remains to be challenging. The aim this study was scrutinize utility three immunohistochemical markers including Forkhead box protein 2 (FOXL2), SOX9, and β-catenin DICER1 mutation status in distinguishing SCTATs from other SCSTs. Nine cases SCTAT, 10 Sertoli-Leydig cell (SC...

Granulosa cell tumors are representative of estrogenic ovarian tumors, and some Sertoli-stromal cell tumors are also estrogenic. The exact cells that are responsible for estrogenesis, however, have yet to be identified. In the present study, 25 sex cord-stromal tumors (20 granulosa cell tumors, 4 Sertoli-Leydig cell tumors, and a Sertoli cell tumor) were immunohistochemically examined for expre...

background: in addition to the well-defined histological criteria for squamous cell carcinoma (scc) and basal cell carcinoma (bcc), immunohistochemical techniques can be used in difficult cases for their differentiation. as differential diagnosis between trichoepithelioma (te) and bcc is sometimes difficult for the clinician and the pathologist, cd10 may be a useful marker for definite diagnosi...

Sertoli-Leydig tumors tend to relapse early and due to their rarity, limited data are available regarding a role of chemotherapy in the management of Sertoli-Leydig cell tumors. We present a case of recurrent ovarian Sertoli-Leydig cell tumor whose salvage treatment was successful with paclitaxel and carboplatin chemotherapy.