The development of a selection procedure is described which utilizes the fact that certain polycyclic aromatic hydrocarbons are rendered highly cytotoxic when illuminated with near-ultraviolet light. Twenty polycyclic aromatic hydrocarbons were screened for phototoxicity and toxicity in the absence of light in the mouse hepatoma line Hepa1c1c7, which has high inducible aryl hydrocarbon hydroxyl...

Article Type: Full Length Research Article Pseudomonas putida HK-44, a bioluminescent reporter strain with a nah-lux fusion, can be used to assess the presence of polynuclear aromatic hydrocarbons by stimulating the light production upon inducing the naphthalene dioxygenase system. However, this assay can be affected by the presence of oxygen. The aim of this work was to evaluate the effect of ...