The impact of combining epidermal growth factor receptor tyrosine kinase inhibitors (EGFR-TKIs) and chemotherapy as first-line therapy for patients with advanced non-small-cell lung cancer (NSCLC) remains controversial. Therefore, randomized trials that compared this combined regimen with chemotherapy or EGFR-TKIs monotherapy were included for this meta-analysis. We used published hazard ratios...

Nevirapine (NVP) and Efavirenz (EFV) have generally comparable clinical and virologic efficacy. However, data comparing NVP durability to EFV are imprecise. We analyzed cohort data to compare durability of NVP to EFV among patients initiating ART in Mbabane, Swaziland. The primary outcome was poor regimen durability defined as any modification of NVP or EFV to the ART regimen. Multivariate Cox ...

BACKGROUND Lymphatic filariasis is targeted for elimination as a public health problem by 2020. The principal approach used by current programmes is annual mass drug administration with two pairs of drugs with a good safety profile. However, one dose of a triple-drug regimen (ivermectin, diethylcarbamazine, and albendazole) has been shown to clear the transmissible stage of the helminth complet...

abstract background: gestational diabetes mellitus is a prevalent pregnancy complication that seriously endangers mothers’ and babies’ health. the aim of this study was to explore factors affecting treatment compliance among women with gestational diabetes mellitus. materials and methods: a qualitative content analysis approach was employed. twenty‑five semi‑structured interviews were conducted...

abstract background: triple therapy with a proton pump inhibitor, clarithromycin and amoxicillin and quadruple therapy with a proton pump inhibitor, bismuth citrate, metronidazole and amoxicillin have been proposed in maastricht 2000 as the optimal treatment of helicobacter pylori infection. we aimed to compare these two regimens in iranian pediatric patients. methods: a randomized clinical tri...

We evaluated the effect of various light/dark regimens on the survival, life span and tumorigenesis in rats. Two hundred eight male and 203 females LIO rats were subdivided into 4 groups and kept at various light/dark regimens: standard 12:12 light/dark (LD); natural lighting of the North-West of Russia (NL); constant light (LL), and constant darkness (DD) since the age of 25 days until natural...

The purpose of the present study was to analyze the effect of a lighting stress on the fluctuating asymmetry (FA), the heterophil-to-lymphocyte ratio, and the tonic immobility duration of chickens. The experiment (440 birds) measured the FA of several traits (outer, middle, inner, and hind toe lengths and leg, wing, second primary feather, and spur lengths), the heterophil-to-lymphocyte ratio, ...

Roseobacter litoralis OCh149 is a type strain of aerobic anoxygenic phototrophic bacteria in marine Roseobacter clade. Its full genome has been sequenced; however, proteomic research, which will give deeper insights into the environmental stimuli on gene expression networks, has yet to be performed. In the present study, a proteomic approach was employed to analyze the status of R. litoralis OC...