نتایج جستجو برای: like receptor 8
تعداد نتایج: 1741774 فیلتر نتایج به سال:
Previous work has shown that certain β(3)-peptides can effectively mimic the side chain display of an α-helix and inhibit interactions between proteins, both in vitro and in cultured cells. Here we describe a β(3)-peptide analog of GLP-1, CC-3(Act), that interacts with the GLP-1R extracellular domain (nGLP-1R) in vitro in a manner that competes with exendin-4 and induces GLP-1R-dependent cAMP s...
Allosteric regulation promises to open up new therapeutic avenues by increasing drug specificity at G-protein-coupled receptors (GPCRs). However, drug discovery efforts are at present hampered by an inability to precisely control the allosteric site. Herein, we describe the design, synthesis, and testing of PhotoETP, a light-activated positive allosteric modulator of the glucagon-like peptide-1...
Aging is accompanied by a progressive decline in immune function. Studies have shown age-related decreases in the expression and signaling efficiency of Toll-like receptors (TLRs) in monocytes and dendritic cells and dysregulation of macrophage TLR3. Using a multivariable mixed effect model, we report a highly significant increase in TLR5-induced production of IL-8 from monocytes of older indiv...
هدف از این پژوهش بررسی میزان متیلاسیون شماری از ژنهای مهم مرغ بود. بدین منظور 32 ژن از genbank انتخاب شد. پروموتورهای این ژنها با نرم افزار promoter prediction پیدا شدند. جزایر احتمالی موجود در هر توالی با نرم افزار cpg island searcher مشخص شدند. احتمال متیله شدن هر رشته dna یک ژن، با نرم افزار methylator و آنالیز متیلاسیون با نرم افزار epigraph انجام شد. در نهایت با استفاده از مدل مارکف پنهان،...
context triple negative breast cancer (tnbc) is a heterogeneous group of diseases that is negative for esterogen receptor (er) progesteron receptor (pr) and human epidermal growth factor receptor 2 (her2). this type of breast cancer is typically high-grade carcinomas, although low-grade tumors occur. the aim of this review is to focus on molecular classification and features, prognostic markers...
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