Annelid erythrocruorins are extracellular respiratory complexes assembled from 180 subunits into hexagonal bilayers. Cryo-electron microscopic experiments have identified two different architectural classes. In one, designated type I, the vertices of the two hexagonal layers are partially staggered, with one hexagonal layer rotated by about 16 degrees relative to the other layer, whereas in the...

The novel connection between Raynaud dise ase and fish oils was uncovered from two disjointed biomedical literature sets by Swanson in 1986. Since then, there have been many approaches to uncover novel connections by mining the biomedical literature. One of the popular approaches is to adapt the Association Rule (AR) method to automatically identify implicit novel connections between concept A ...

Principles of narrative and intellectual film editing were investigated by assessing the semantic, cognitive, and aesthetic consequences of inserting flashbacks. A short narrative film was presented, either with flashbacks or in chronological/linear order. In Experiment 1, the gravity of the acts committed by the two main actors was perceived to be more salient in the linear than in the flashba...

Heated debates on given models of treatment for drug users have raged in the halls of academia, in public policies, not to mention in the media. The care network on drugs is presented in this context as an important mechanism for users, but its construction turns out to be a challenge. Therefore, a critical analysis and narrative review of the scientific literature on the care network on drugs ...

Studies of how 10 to 11 year old children understand eventbased program descriptions based on comic strips showed that narrative interpretations of such programs were common. A narrative perspective was taken both when using paper prototypes and computer prototypes, but was stronger on paper than on the computer. While a narrative model of programming can interfere with the creation of non-line...

A linear-linear piecewise growth mixture model (PGMM) is appropriate for analyzing segmented (disjointed) change in individual behavior over time, where the data come from a mixture of 2 or more latent classes, and the underlying growth trajectories in the different segments of the developmental process within each latent class are linear. A PGMM allows the knot (change point), the time of tran...

Using the example of a failed software implementation, we discuss the role of artifacts in shaping organizational routines. We argue that artifact-centered assumptions about design are not well suited to designing organizational routines, which are generative systems that produce recognizable, repetitive patterns of interdependent actions, carried out by multiple actors. Artifact-centered assum...

BACKGROUND Sharing interim data, results or result extrapolations is an important issue that can affect trial integrity. The different ways in which Data Safety Monitoring Boards (DSMBs) share interim results with non-DSMB members and the acceptability of such practices are poorly understood. Our objective was to undertake a narrative review specifically on what kind of interim results, if any,...