We find that ectopic expression of Delta or Serrate in neurons within developing bristle organs is capable of non-autonomously inducing the transformation of the pre-trichogen cell into a tormogen cell in a wide variety of developmental contexts. The frequencies at which Delta can induce these transformations are dependent on the level of ectopic Delta expression and the levels of endogenous No...

linguatula serrata is one of well-known members of pentastomida which infects both humans and animals. the aim of this study was to evaluate the prevalence of l. serrata in mesenteric lymph nodes, livers and lungs of goats slaughtered in tabriz area, iran. mesenteric lymph nodes (mlns), livers and lungs of 280 goats slaughtered in tabriz, north-west of iran were investigated for nymphs of l. se...

Cellular microenvironments established by the spatial and temporal expression of specific signaling molecules are critical for both the maintenance and lineage-specific differentiation of progenitor cells. In Drosophila, a population of hematopoietic progenitors, or prohemocytes, within the larval lymph gland gives rise to three mature cell types: plasmatocytes, lamellocytes, and crystal cells....

In vertebrate limb, a group of specialized epithelial cells called Apical Ectodermal Ridge (AER) form at the boundary of dorsal and ventral limb ectoderm. Recent experiments suggest that AER forms at the boundary of Fringe expressing and Fringe non-expressing cells by a specific type of receptor-ligand interaction called as inductive signaling, involving the transmembrane proteins Notch, Serrat...

T he maturation and quality control of mRNA in eukaryotes is a tightly regulated, multistep process that begins on nascent transcripts. A 7-methyl guanosine (7MeG) cap structure is added to the 5 end of pre-mRNA as it emerges from the exit channel of RNA Polymerase II. The multifunctional nuclear cap-binding complex (CBC), consisting of two protein subunits (CBP80 and CBP20), assembles at the p...

5. Hepatic granuloma due to a nymph of Linguatula serrata in a woman from Michigan: a case report and review of the literature. Am J Trop Med Hyg. 1984;33:187–9. 6. A nodular pulmonary lesion due to Linguatula serrata in an HIV-positive man. Two cases of human infestation by larvae of Linguatula serrata. To the Editor: Rates of illness and death from Clostridium difficile–asso-ciated disease (C...

MicroRNAs (miRNAs) function as sequence-specific guides that control gene expression by post-transcriptional gene silencing. Many miRNAs influence plant development by regulating the accumulation of transcripts that encode transcription factors. Mutants defective in miRNA accumulation, such as dcl1, hen1, hyl1 and ago1, have pleiotropic developmental phenotypes. The serrate-1 (se-1) mutant of A...

The Drosophila eye disc is a sac of single layer epithelium with two opposing sides, the peripodial membrane (PM) and the disc proper (DP). Retinal morphogenesis is organized by Notch signaling at the dorsoventral (DV) boundary in the DP. Functions of the PM in coordinating growth and patterning of the DP are unknown. We show that the secreted proteins, Hedgehog, Wingless, and Decapentaplegic, ...