PURPOSE To record visual and refractive data in eyes with previous radial keratotomy (RK) and corneal instability undergoing corneal cross-linking (CXL). METHODS Case series of eyes with RK and refractive instability undergoing CXL with riboflavin and UV-A radiation. The following variables were recorded before 3 and 6 months after CXL: sphere, spherical equivalent (SE), uncorrected visual ac...

OBJECTIVE UV-A/Riboflavin cross-linking of corneal collagen fibers (CXL) is a highly promising therapy for corneal melting in humans. A prospective interventional, nonrandomized, controlled study was conducted to compare the stabilizing effect of CXL treatment on melting keratitis in dogs and cats and the complication rate of CXL to those of standardized intensive medical treatment. PROCEDURE...

PURPOSE To report a case of infectious keratitis after small incision lenticule extraction (SMILE) treated with collagen cross-linking with photoactivated riboflavin (PACK-CXL). METHODS Case report and literature review. RESULTS A patient presented with culture-proven bacterial keratitis 5 days after SMILE was treated with fortified topical antibiotics and PACK-CXL. Irrigation of the cornea...

Corneal collagen cross-linking (CXL) is a safe and effective technique for the management of corneal ecstatic disorders. It has been proven that CXL is effectual in stopping the progression of keratoconus quasi ‘freezing’ the cornea and in many cases avoiding corneal transplantation. Nevertheless, patients’ basic problem, which is the deterioration of their vision due to irregular astigmatism, ...

PURPOSE To report the effect of wavefront-guided photorefractive keratectomy and corneal collagen cross-linking (CXL) on visual problems after Ferrara ring segment placement. MATERIALS AND METHODS A 32-year-old male patient was treated with a Ferrara ring segment for keratoconus. One year later, the ring was removed due to severe glare complaints. After 6 months, wavefront-guided photorefract...

PURPOSE To report the long-term clinical outcome of a patient diagnosed as having Terrien marginal degeneration (TMD) who was subjected to corneal collagen cross-linking (CXL) with ultraviolet-A and riboflavin in both eyes. METHODS Topographical changes were assessed by high-resolution Scheimpflug imaging and anterior segment optical coherence tomography. Eccentric epithelium-off CXL was perf...

BACKGROUND Scleral cross-linking (CXL) is a novel attempt to slow down the axial elongation process in animal eyes. As a natural CXL reagent, genipin would be also effective for the prevention of myopia process. Thus, the present study was designed to evaluate the effects of scleral cross-linking using genipin on the form-deprivation (FD) myopia process of guinea pigs. METHODS Twenty-seven 3-...

PURPOSE To present light and electron microscopic as well as immunohistochemical findings after corneal cross-linking (CXL). METHODS Six keratoconus corneas after CXL, 12 keratoconus corneas without CXL, and 7 normal corneas were examined by light microscopy, indirect immunohistochemistry using antibodies against proapoptotic BAX, antiapoptotic survivin, and BCL-2, and anti-smooth muscle acti...

PURPOSE When treating peripheral ectatic disease-like pellucid marginal degeneration (PMD), corneal cross-linking with UV-A and riboflavin (CXL) must be applied eccentrically to the periphery of the lower cornea, partly irradiating the corneal limbus. Here, we investigated the effect of standard and double-standard fluence corneal cross-linking with riboflavin and UV-A (CXL) on cornea and corne...