In this issue of the Journal, Lee and colleagues 1 from Hong Kong describe their assessment of the impact of the 2001 Bethesda System (TBS) revisions on their cytology practice. The primary focus of the study was to assess the impact of the conversion from TBS 1991 to the 2001 version on the frequency of atypical squamous cells (ASC) diagnoses. As noted in prior commentaries, ASC is not a diagn...

BACKGROUND Although testing for human papillomavirus (HPV) has higher sensitivity and lower specificity than cytology alone for detecting cervical intraepithelial neoplasia (CIN), studies comparing conventional and liquid-based cytology have had conflicting results. METHODS In the first phase of a two-phase multicenter randomized controlled trial, women aged 35-60 years in the conventional ar...

Since the introduction of the Pap smear by George Papanicolaou, cervical cytology has become the main diagnostic tool to detect cervical cancer. Nowadays cervical cytology is not only used for the detection of overt cancer cells, but also for finding precursor lesions of cervical cancer—that is, cervical intraepithelial lesions grades I–III (CIN). The success of cervical cytology has often been...

Objective To compare the cumulative incidence of cervical cancer diagnosed within 72 months after a normal screening sample between conventional cytology and liquid based cytology tests SurePath and ThinPrep.Design Retrospective population based cohort study.Setting Nationwide network and registry of histo- and cytopathology in the Netherlands (PALGA), January 2000 to March 2013.Population Wome...

BACKGROUND Human papillomavirus (HPV) infections are associated with cervical cancer. There were only a few reports and detailed data about epidemiological research of HPV infection in general population of China. AIMS To determine the prevalence of genital HPV infection in Chinese women of Guangdong province. METHODS A total of 1705 women were screened by gene chip. All HPV-positive women ...

conclusions specimen adequacy and diagnosis of inflammatory reaction were better in liquid base smear and convention smear, respectively. results specimen adequacy and smear quality were significantly better in liquid base sampling (p = 0.03); presence of benign cellular changes was not different between the two groups (p = 0.389). diagnosis of bacterial vaginosis was significantly better with ...