Summary At the turn of past century, unresectable metastatic melanoma was primarily treated with different chemotherapeutic agents, such as dacarbazine, only poor efficacy. Immunotherapeutic interleukin‑2 or adjuvant interferon alpha, were used modest results but frequent side effects. In last 10 years, modern immunotherapy using checkpoint inhibition has dramatically changed treatment landscap...

Posttranscriptional regulation is of critical importance during mammalian spermiogenesis. A set of mRNAs that encode proteins critical to normal sperm formation are synthesized early in the process of male germ cell differentiation and are stored in a repressed state. These mRNAs are subsequently translationally activated during the process of spermatid elongation and maturation. Of note, the t...

OBJECTIVE To determine the time course of changes in glucagon and insulin secretion in children with recently diagnosed type 1 diabetes. RESEARCH DESIGN AND METHODS Glucagon and C-peptide concentrations were determined in response to standard mixed meals in 23 patients with type 1 diabetes aged 9.4 +/- 4.6 years, beginning within 6 weeks of diagnosis, and every 3 months thereafter for 1 year....

A growing frustration in clinical medicine is that we are now so busy managing the proliferation of risk factors, “incidentalomas,” and the worried well that we lack the time to care properly for those who are seriously ill. As the definitions of common conditions such as diabetes and kidney disease have expanded and the categories and boundaries of mental disorders have grown, our time and att...

the Nuclear Regulatory Com mission (NRC) by the Society ofNuclear Medicine and the American College ofNuclear Physiciansover four years ago is finally getting some response. The reaction from the peti tion's original author, however, has been less than favorable. Carol S. Marcus, PhD, MD, Director of Nuclear Medicine and Outpatient Clinic atHarbor-UCLAMedicalCenter and the principalauthorof the...