Gap junctions are composed of protein subunits, called connexins, and provide a pathway for the exchange of ions and small molecules between contacting cells. This transfer of molecules is thought to be an important pathway for direct cell communication, and is involved in tissue homeostasis, growth control and embryonic development. Impairment of gap junctional intercellular communication (GJI...

gastrointestinal stromal tumors are mesenchymal neoplasms of the gastrointesti- nal tract that originate from all areas of the gastrointestinal tract. metastases to the liver, peritoneum, bones, lungs and soft tissues have been reported. we present the case of a 47- year-old woman with rectal gastrointestinal stromal tumor that underwent wide local excision. she was treated with imatinib for a ...

Hepatocellular lesions can be neoplastic or non-neoplastic. The common non-neoplasms include regenerative hyperplasia, focal accumulation of fat, focal nodular hyperplasia (FNH), macroregenerative nodules (MRN), and nodular regenerative hyperplasia (NRH). The neoplasms include hepatic adenomas, hepatocellular carcinomas (HCC) and their variants. Accurate diagnosis of these lesions can be someti...

1. Purpose: The treatment of hepatic neoplasms has undergone, in recent years, various evolution the surgical technique and extension to indication for resection. Many patients with liver tumors cannot benefit from resection due difficulty anatomical site lesion.Of these patients, only some can ex vivo resection, which consists a complete hepatectomy, bench tumor self-transplant. 2. Materials m...

hepatocellular carcinoma (hcc) represents one of the most common neoplasms worldwide.  liver trasnplantation (lt) is the treatment of choice for selected group of patients with hcc. lt is actually a consolidated therapeutic option for hcc because it cures both tumor and underlying cirrhosis. in 1996, the publication of a pivotal prospective study on less than 50 patients, transplanted for hcc u...

BACKGROUND & AIMS Elevated serum alanine aminotransferase (ALT) and gamma-glutamyltransferase (GGT) activities are markers of liver injury, but may also be associated with other diseases and death. In a prospective, national, population-based sample, we examined whether elevated ALT and GGT were associated with increased risk of all-cause and disease-specific mortality. METHODS Death certific...

Pediatric liver tumors account for approximately 1% of all liver tumors and up to 2% of all pediatric malignancies [1,2]. While the overall incidence of liver tumors is rare, the liver remains the third most common organ of origin for solid abdominal tumors in the pediatric population [3]. The majority of pediatric liver tumors, both benign and malignant, occur (almost) exclusively in children....