To the Editor: Dhir et aL ~ should be congratulated for successfully administering regional anesthesia to a small series of patients with Charcot-Marie-Tooth disease. In reading the aforementioned case reports, it not only becomes apparent that dissimilar approaches to the brachial plexus were utilized but also that different local anesthetic solutions and volumes were employed. 1 Universally a...

Arthroscopy is performed with increasing frequency on a number of joints. In the lower limb the role of knee arthroscopy is well established with procedures enabling more accurate diagnosis and treatment of a myriad of conditions including but not being limited to meniscal injury and articular surface defects. Hip and ankle arthroscopy are less widely performed. However, despite this their use ...

BACKGROUND Local anesthetics that produce analgesia of long duration with minimal impairment of autonomic functions are highly desirable for pain management in the clinic. Prenylamine is a known calcium channel blocker, but its local anesthetic blocking effects on voltage-gated sodium channels have not been studied thus far. METHODS The authors characterized the tonic and use-dependent prenyl...

The first clinical uses of a local anesthetic agent occurred in 1884, when cocaine was employed as a topical agent for eye surgery and to produce a nerve block. These events inaugurated a new era, that of regional anesthesia. New applications were developed, including spinal, epidural, and caudal anesthesia. The search for a better local anesthetic led to chemical synthesis of a number of other...