Pemphigus foliaceus, also known as fogo selvagem, is an autoimmune disease of the epidermis characterized by superficial blisters and antibodies against desmoglein 1. It is a multifactorial disease and genetic susceptibility is oligogenic or polygenic. Considering the crucial function of the programmed cell death 1 molecule (PD-1) in the immune response, the aim of this study was to verify if v...

Pemphigus foliaceus (PF) is rarely described in the pediatric population with less than 40 cases reported in the literature. We report the case of an 11-year-old girl who was diagnosed with PF after 6 months of starting with symptoms and who responded well to therapy with oral dapsone. Although therapeutic guidelines for PF in children are lacking, oral corticosteroids in combination with dapso...

A 68-year-old woman who had had pemphigus foliaceus for 13 years, presented for initiation of more aggressive therapy due to gradual continuous clinical worsening in the last 3 months despite potent topical steroid and long-standing systemic therapy with prednisolone 50 mg/day for one year. At the time of presentation desmoglein-1 antibodies were detectable to a low grade using enzyme-linked im...

The importance of cellular infiltrates in tissues has been investigated as a diagnostic tool, mechanism of pathogenesis, and prognostic indicator in certain human diseases. Eosinophils, in particular, have a distinct role in the development of cutaneous lesions in human autoimmune diseases. Identification of an eosinophilic infiltrate can aid the diagnosis of immunobullous disease in the early ...

Fogo Selvagem (FS) is an endemic form of pemphigus foliaceus (PF) which is prevalent in certain regions of Brazil (Diaz et al., 1989). Genetic and environmental factors such as insect bites may contribute to the development of FS (Aoki et al., 2004; Diaz et al., 1989; Moraes et al., 1997). Blister formation in FS is mediated by predominantly IgG4 antidesmoglein 1 (Dsg1) antibodies (Rock et al.,...