Users of automated scheduling systems frequently require an interactive approach to scheduling where they can manually modify the schedules. Because of complexity and cohesion of scheduling relations, it may happen that manual modification introduces flaws to the schedule, namely the altered schedule violates some constraints such as precedence relations or limited capacity of resources. It is ...

In many sequential decision-making problems we may want to manage risk by minimizing some measure of variability in rewards in addition to maximizing a standard criterion. Variance-related risk measures are among the most common risk-sensitive criteria in finance and operations research. However, optimizing many such criteria is known to be a hard problem. In this paper, we consider both discou...

In this paper, we study a geometric G^2 Hermite interpolation by planar rational cubic Bézier curves. Two data points, two tangent vectors and two signed curvatures interpolated per each rational segment. We give the necessary and the sufficient intrinsic geometric conditions for two C^2 parametric curves to be connected with G2 continuity. Locally, the free parameters w...

A risk-minimizing portfolio model under uncertainty with randomness and fuzziness is discussed. By a perception-based extension of estimations for fuzzy random variables, the risk-minimizing portfolio problem is developed. In the uncertainty model, the randomness and fuzziness are evaluated respectively by the probabilistic expectation and mean values with evaluation weights and -mean functions...

Current treatments for methicillin-resistant Staphylococcus aureus (MRSA) infections require intravenously delivered vancomycin; however, systemically delivered vancomycin has its problems. To determine the feasibility and safety of locally delivering vancomycin hydrochloride (~25 mg/Kg) to the medullary canal of long bones, we conducted a pharmacokinetics study using a rat tibia model. We foun...