The basement membrane protein laminin-332 (laminin-5) mediates both stable cell adhesion and rapid cell migration and thus has the potential to either restrain or promote tumor cell metastasis. The major cellular receptors for laminin-332 are integrin α3β1, which mediates rapid tumor cell migration, and integrin α6β4, which often mediates stable cell attachment. Tetraspanin protein CD151 intera...

A bio-inspired multifunctionalized silk fibroin (BMS) was synthesized in order to mimic the interaction of nidogen with type IV collagen and laminin basement membranes. The designed BMS consists a motif ?-chain-derived, called IK peptide, covalently bound (SF) by using EDC/NHS coupling Cu-free click chemistry reaction, respectively. Silk chosen as main component because it is versatile biocompa...

Engineering of biomaterials with specific biological properties has gained momentum as a means to control stem cell behavior. Here, we address the effect of bifunctionalized hydrogels comprising polylysine (PL) and a 19-mer peptide containing the laminin motif IKVAV (IKVAV) on embryonic and adult neuronal progenitor cells under different stiffness regimes. Neuronal differentiation of embryonic ...

abstract   background: squamous cell carcinoma (scc) constitutes the main oral malignancy . parallel to better understanding of molecular and genetic patterns of tumor behavior, more precise correlation of tumor markers such as epidermal growth factor (egf) and laminin-5 are sought to estimate macroscopic and microscopic tumor status .   methods: we conducted a cross-sectional study collecting ...

the comparative research about the common features and roots of the shāh-nāme, the most renowned iranian national epic and the most comprehensive and authoritative source of heroic narratives, with other works of the same nature in verse and prose is a long story and cannot be adequately addressed in a limited scope. however, the present article aims at describing one or more common aspects. on...

We describe the identification of a novel laminin chain. Overlapping clones were isolated from a human fibrosarcoma HT1080 cell cDNA library spanning a total of 5,200 bp. A second set of clones contained an alternative 3' end sequence giving a total of 4,316 bp. The longer sequence contained an open reading frame for a 1,193-residue-long polypeptide. The alternative sequence was shortened at th...

Laminin self-assembles into a basement membrane polymer through specific low-affinity interactions. Recently, it was shown that the terminal short-arm domain (domains VI and V) of the B1 chain (fragment E4) possesses one of the laminin self-interaction sites [Schittny, J.C. & Yurchenco, P.D. (1990) J. Cell Biol. 110, 825-832], but that the binding partner(s) of this domain is unknown. Using aff...