The gas–liquid hydrodynamics and mass transfer were studied in a concentric tube internal jet-loop airlift reactor with conical bottom. Comparing standard design, the gas separator was equipped an adjustable deflector placed above riser. effect of riser superficial velocity uSGR on total holdup ?GT, homogenization time tH, overall volumetric liquid-phase coefficient kLa investigated laboratory ...

Continuous fermentations were carried out with a recombinant flocculent Saccharomyces cerevisiae strain in an airlift bioreactor. Once operating under steady state at a dilution rate of 0.45 h(-1), the bioreactor was contaminated with Escherichia coli cells. The faster growing E. coli strain was washed out of the bioreactor and the recombinant, slower growing flocculating S. cerevisiae strain r...

In this work, a new adaptive controller is designed for substrate control of fed-batch bioreactor in the presence input saturation and unknown varying gain with upper lower bounds. The output measurement noise nature reaction rate biomass concentration water volume are also handled. design based on dead zone quadratic forms. ensures convergence modified tracking error boundedness updated parame...

Performance efficiency in a Downflow Hanging Sponge (DHS) bioreactor is associated with the amount of time that a wastewater remains in the bioreactor. The bioreactor is considered as a plug flow reactor and its hydraulic residence time (HRT) depends on the void volume of packing material and the flow rate. In this study, hydraulic behavior of DHS bioreactor was investigated by using tracer met...

Mercury-contaminated chemical wastewater of a mercury cell chloralkali plant was cleaned on site by a technical-scale bioremediation system. Microbial mercury reduction of soluble Hg(II) to precipitating Hg(0) decreased the mercury load of the wastewater during its flow through the bioremediation system by up to 99%. The system consisted of a packed-bed bioreactor, where most of the wastewater'...

Recent advances in mammalian, insect, and stem cell cultivation and scale-up have created tremendous opportunities for new therapeutics and personalized medicine innovations. However, translating these advances into therapeutic applications will require in vitro systems that allow for robust, flexible, and cost effective bioreactor systems. There are several bioreactor systems currently utilize...

The skin is susceptible to different injuries and diseases. One major obstacle in skin tissue engineering is how to develop functional three-dimensional (3D) substitute for damaged skin. Previous studies have proved a 3D dynamic simulated microgravity (SMG) culture system as a "stimulatory" environment for the proliferation and differentiation of stem cells. Here, we employed the NASA-approved ...

Widespread use of human umbilical cord cells for cardiovascular tissue engineering requires production of large numbers of well-characterized cells under controlled conditions. In current research projects, the expansion of cells to be used to create a tissue construct is usually performed in static cell culture systems which are, however, often not satisfactory due to limitations in nutrient a...

The removal of trace organic compounds (TrOCs) by a novel membrane distillation-thermophilic bioreactor (MDBR) system was examined. Salinity build-up and the thermophilic conditions to some extent adversely impacted the performance of the bioreactor, particularly the removal of total nitrogen and recalcitrant TrOCs. While most TrOCs were well removed by the thermophilic bioreactor, compounds co...