نتایج جستجو برای: low dose interferon
تعداد نتایج: 1503914 فیلتر نتایج به سال:
background: the specific antibody response against newcastle disease virus (ndv) in the blood serum of chickens hatched from eggs exposed to low dose gamma-radiation was studied. materials and methods: two groups of eggs of commercial meat chicken lines were irradiated with the dose of 0.30 gy 60co gamma-rays before incubation and on the 19th day of incubation, respectively. the same number of ...
Treatment with interferon alfa combined with ribavirin is successful in approximately 40% to 45% of patients with chronic hepatitis C viral infection (HCV). However, response rates are disappointing in patients who are difficult to treat, such as those infected with HCV genotype 1, high viral load, or advanced liver fibrosis. In addition, low tolerability and significant side effects of therapy...
BACKGROUND GS-9620 is a potent oral agonist of toll-like receptor 7, a key modulator of the innate immune response. In healthy volunteers, low doses of GS-9620 (2, 4 and 6 mg) induced significant expression of peripheral interferon-stimulated-gene (ISG) mRNA in the absence of detectable serum interferon-α and systemic adverse events (AEs). We evaluated the safety, pharmacokinetics and pharmacod...
Imiquimod [1-(2-methylpropyl)-1H-imidazo[4,5c]quinolin-4-amine] is a compound of low molecular weight that, when administered p.o., induces interferon-alpha in several animal species and inhibits tumor growth in mice. To determine maximum tolerated dose, toxicity, and biological response in humans, a phase I clinical trial was conducted with 14 eligible cancer patients who received 100-500 mg i...
Adjuvant therapy for patients with melanoma using interferon remains controversial despite numerous randomized clinical trials. There can be no doubt that interferon works—that is, it has biologic activity sufficient to alter the natural history of resected melanoma. Multiple randomized trials have demonstrated that adjuvant interferon prolongs recurrence free survival compared with observation...
abstract a field experiment was conducted at plant pest and disease research institute in karaj,iran in 2005-2006 to determine the effect of low herbicide dose of clodinafop-propargyl on percentage of wild oat control, yield and economic return of wheat. the experiment included 2 wheat varieties (rooshan and niknejad (less and more competitiveness cultivar, respectively, 4 wild oat densities (0...
background: study of vascular and its secretory profile changes is an important issue in pathogenesis of radiation myelopathy. this paper reports the prostacyclin concentration changes after low-moderate doses of x-irradiation within a short period of time. materials and methods: cervical cords of wistar rats were irradiated to doses of 0.5, 1, 2, 4 and 6 gy x-rays. after 24 hours, 2 and 13 wee...
OBJECTIVE To determine the effect of low dose interferon alfa (human lymphoblastoid interferon) on aminotransferase activities in chronic non-A non-B hepatitis. DESIGN Prospective randomised controlled parallel group study of active treatment versus no treatment carried out over 16 weeks and preceded by baseline measurements at weeks 8 and 4 and time zero. SETTING HEPATOLOGY outpatient clin...
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