felodipine is a second generation calcium channel blocker widely used as antihypertensive and antianginal drug which belongs to bcs class ii category. hence, its low water solubility limits the pharmacological effect. the aim of this study was to improve the dissolution rate of felodipine using spherical agglomeration technique with acetone, water and dichloromethane as good solvent, poor solve...

Abstract We obtain a Serrin-type symmetry of the solutions to various overdetermined boundary value problems in annular domains with spherical-boundary component space forms by using maximum principle for suitable subharmonic functions and integral identities.

Motivated by potential applications in architecture, we study Darboux cyclides. These algebraic surfaces of order ≤ 4 are a superset of Dupin cyclides and quadrics, and they carry up to six real families of circles. Revisiting the classical approach to these surfaces based on the spherical model of 3D Möbius geometry, we provide computational tools for the identificiation of circle families on ...

For multicomponent vesicles, the line tension of domain boundaries and the component-dependent elastic properties (e.g., spontaneous curvatures) are the two most important factors that mediate the budding behaviors of these vesicles. This paper especially focuses on their effects on the budding types and the budding number of a two-component vesicle. We found that the budding number is mainly d...

In this paper we determine all non-trivial self-motions of TSSM manipulators with two parallel rotary axes which equals the determination of all flexible octahedra where one vertex is an ideal point. This study also closes the classification of these motions for the whole set of parallel manipulators of TSSM type. Our approach is based on Kokotsakis meshes and the reducible compositions of sphe...