lxrβ

Christian Beyer Jingang Huang Jürgen Beer Yun Zhang Katrin Palumbo-Zerr Pawel Zerr Alfiya Distler Clara Dees Christiane Maier Louis Munoz Gerhard Krönke Stefan Uderhardt Oliver Distler Simon Jones Stefan Rose-John Tamas Oravecz Georg Schett Jörg H W Distler

OBJECTIVES To investigate the role of liver X receptors (LXRs) in experimental skin fibrosis and evaluate their potential as novel antifibrotic targets. METHODS We studied the role of LXRs in bleomycin-induced skin fibrosis, in the model of sclerodermatous graft-versus-host disease (sclGvHD) and in tight skin-1 (Tsk-1) mice, reflecting different subtypes of fibrotic disease. We examined both ...

متن کامل

Identification of 5α, 6α-epoxycholesterol as a novel modulator of liver X receptor activity.

Journal: :Molecular pharmacology 2010

Thomas J Berrodin Qi Shen Elaine M Quinet Matthew R Yudt Leonard P Freedman Sunil Nagpal

The liver X receptors (LXRα and LXRβ) are members of the nuclear receptor superfamily that function as key transcriptional regulators of a number of biological processes, including cholesterol homeostasis, lipid metabolism, and keratinocyte differentiation. Natural ligands that activate LXRs include oxysterol derivatives such as 25-hydroxycholesterol, 27-hydroxycholesterol, 22(R)-hydroxycholest...

متن کامل

نمودار تعداد نتایج جستجو در هر سال

با کلیک روی نمودار نتایج را به سال انتشار فیلتر کنید

Identfication of Potent LXRβ-Selective Agonists without LXRα Activation by In Silico Approaches

Alterations of LXRα and LXRβ expression in the hypothalamus of glucose-intolerant rats

LXRβ Is Required for Adipocyte Growth, Glucose Homeostasis, and β Cell Function

Separating the Anti-Inflammatory and Diabetogenic Effects of Glucocorticoids Through LXRβ Antagonism

LXRβ controls glioblastoma cell growth, lipid balance, and immune modulation independently of ABCA1

Activation of liver X receptors inhibits experimental fibrosis by interfering with interleukin-6 release from macrophages.

Identification of 5α, 6α-epoxycholesterol as a novel modulator of liver X receptor activity.

The oxysterol receptor LXRβ protects against DSS- and TNBS-induced colitis in mice

Oxysterol Nuclear Receptor LXRβ Regulates Cholesterol Homeostasis and Contractile Function in Mouse Uterus

Transcriptional regulation of homeostatic and disease‐associated‐microglial genes by IRF1, LXRβ, and CEBPα