Phosphonoformate and recombinant alpha-A interferon synergistically inhibited the replication of human T-cell lymphotropic virus type III in cultured peripheral blood lymphocytes. T-cell proliferative capability was maintained by this combination, and toxicity was minimal.

introduction: transfusion-transmitted infections (tti) continue to be a major challenge for blood transfusion organizations in the world and multi- transfused patients (mtps) are at higher risk of infection. htlv-1 is a retrovirus that easily transmitted via blood cell products. the aim of this study is determine the seroprevalence of htlv-1 in major thalassemic patients from kermanshah provinc...

We compared an antigen capture assay (Abbott Laboratories, North Chicago, Ill.) with a reverse transcriptase assay to identify and quantify human immunodeficiency virus (HIV) in culture. In direct comparisons of serial dilutions of lymphadenopathy-associated virus type 1, the antigen assay was 100-fold more sensitive than the reverse transcriptase assay in detecting the virus. The antigen assay...

amyotrophic lateral sclerosis is a progressive neurodegenerative disease with uncertain etiology. for many years, viruses have been suspected as causative agents. there are conflicting reports about the possible role of viruses such as human herpes virus 8 (hhv8) and retroviruses in the pathogenesis of the sporadic amyotrophic lateral sclerosis. we conducted a prospective case-control study to ...

The Brazilian Ministry of Health recommends the performance of serological tests in patients with clinical signs of Sexually Transmitted Diseases. However, data are lacking to affirm the necessity of testing these patients for human T-lymphotropic virus type 1 or type 2. This is a cross-sectional study with 120 patients seen at the Sexually Transmitted Diseases unit of the Sanitary Dermatology ...

Infective dermatitis is a chronic exudative eczematous eruption presenting in human T-lymphotropic virus type 1 (HTLV-1)-infected people. It presents with relapsing erythematous, scaly, and crusted lesions affecting simultaneously the scalp, external ear, retroauricular area, eyelid, paranasal skin, neck axilla, and groin. Superimposed Staphylococcus and Streptococcus infection are common. It m...

Identification of microRNA (miRNA) precursors has seen increased efforts in recent years. The difficulty in experimental detection of pre-miRNAs increased the usage of computational approaches. Most of these approaches rely on machine learning especially classification. In order to achieve successful classification, many parameters need to be considered such as data quality, choice of classifie...