selenium plays an important role in biological system due to its incorporation in glutathione peroxidases and thioredoxin reductase as prosthetic group, the pharmacological studies of synthetic organoseleno-compounds revealed these molecules to be used as antioxidants, enzyme inhibitors, neuroprotectors, antitumor, anti-infectious agents, cytokine inducers and immuno-modulators. the present stu...

different contraceptive methods are used by breastfeeding mothers. in general, these methods are classified into two major groups, hormonal and non-hormonal. a number of studies have shown that combined oral contraceptive pills may adversely affect the quality and the quantity of human milk. in other studies it has been shown that estrogen and progesterone seem to reduce the risk of cardiac and...

objective(s):   zinc oxide nanoparticles (znp) are increasingly used in sunscreens, biosensors, food additives and pigments. in this study the effects of znp on liver of rats was investigated.     materials and methods: experimental groups received 5, 50 and 300 mg/kg znp respectively for 14 days. control group received only distilled water. alt, ast and alp were considered as biomarkers to ind...

BACKGROUND/AIMS The impact of nebivolol therapy on the renal proximal tubular cell (PTC) structure and function was investigated in a transgenic (TG) rodent model of hypertension and the cardiometabolic syndrome. The TG Ren2 rat develops nephropathy with proteinuria, increased renal angiotensin II levels and oxidative stress, and PTC remodeling. Nebivolol, a beta(1)-antagonist, has recently bee...

Lycopene is common in diet and known for its antioxidant activities. However, the impact of lycopene on iron metabolism is poorly investigated. In this study, we hypothesize that lycopene can prevent iron-mediated oxidative stress, proliferation and autophagy in liver and use a rat model of nutritional iron supplementation to confi rm its intervention in these defence mechanisms. We found that ...

Nanotechnologies promise new means for drug delivery. ICAM-1 is a good target for vascular immunotargeting of nanoparticles to the perturbed endothelium, although endothelial cells do not internalize monomeric anti-ICAM-1 antibodies. However, coupling ICAM-1 antibodies to nanoparticles creates multivalent ligands that enter cells via an amiloride-sensitive endocytic pathway that does not requir...

background: recently, it has been revealed that tyrosine kinase inhibitors (tkis) act through inducing both oxidative and endoplasmic reticulum (er) stress in chronic myeloid leukemia cells. however, er stress signaling triggers both apoptotic and survival processes within cells. nevertheless, mechanisms by which tkis avoid the pro-survival effects are not clear. the aim of this study was to ev...

background: acetaminophen (apap) overdose causes renal and hepatic injury. it is ‎also believed that oxidative stress has a pivotal role in apap-induced renal injury. ‎therefore, protective effects of different antioxidants have been examined in apap-‎induced renal and hepatic toxicity models. stevia rebadiana is a plant with a high ‎degree of natural antioxidant activity in its leaf extract. t...