We appreciate the letter to the editor by Alkan et al. [1] in response to our recently published article [2]. Alkan et al. bring up some potentially valid points about our study. They suggest rheumatic diseases should have been excluded from the study population, as these conditions are ‘important causatives for chronic inflammation.’ They also suggest the inclusion of elderly subjects older th...

Eight quinolones were examined for their bacterial mutagenicity in the Ames Salmonella TA102 assay and for their effects in other bacterial genotoxicity assays. In the quantitative Ames plate incorporation assay, all eight quinolones induced His+ deletion reversion in Salmonella tester strain TA102, with maximum reversion observed at about two to eight times the MIC. The quinolones also induced...

Detection of viral nucleic acids is central to antiviral immunity. Recently, DAI/ZBP1 (DNA-dependent activator of IRFs/Z-DNA binding protein 1) was identified as a cytoplasmic DNA sensor and shown to activate the interferon regulatory factor (IRF) and nuclear factor-kappa B (NF-kappaB) transcription factors, leading to type-I interferon production. DAI-induced IRF activation depends on TANK-bin...

Abstract Micromodel can provide valuable information to improve understanding of pore-scale transport phenomenon and also be utilized simulate the process at pore scale. This research aims propose settlement option for quantification suspended solids in micromodel. The micromodel is used mimic formation damage which occurs reservoir that could simultaneously affect enhanced oil recovery. done b...

Massive exploration effort in the study area was conducted 1996-2014 when deep-water drilling campaign found significant oil and gas discoveries but yet to optimally reach middle Miocene sandstone reservoirs. Outcrops, well bores 2D-seismic data had been incorporated this study. Datum age from several taxon indicators have utilized correlate unify various markers across into four key biostratig...

X-ray magnetic circular dichroism (XMCD) measurements on Yb14MnSb11 provide experimental evidence of a moment of 5 microB on Mn, with partial cancellation by an opposing moment on the Sb4 cage surrounding each Mn ion. The compound is isostructural to Ca14AlSb11, with Mn occupying the Al site in the AlSb4(9-) discrete tetrahedral, anionic unit. Bulk magnetization measurements indicate a saturati...

Data-intensive distributed file systems are emerging as a key component of large scale Internet services and cloud computing platforms. They are designed from the ground up and are tuned for specific application workloads. Leading examples, such as the Google File System, Hadoop distributed file system (HDFS) and Amazon S3, are defining this new purpose-built paradigm. It is tempting to classif...

Human cytomegalovirus (HCMV) encodes a protein related to the large (R1) subunit of ribonucleotide reductase (RR), but does not encode the corresponding small (R2) subunit. The R1 homologue, UL45, lacks many catalytic residues, and its impact on deoxyribonucleotide (dNTP) production remains unknown. Here, UL45 is shown to accumulate at late stages of infection and to be a virion tegument protei...

Given a graph with billions of nodes and edges, how can we find patterns and anomalies? Are there nodes that participate in too many or too few triangles? Are there close-knit near-cliques? These questions are expensive to answer unless we have the first several eigenvalues and eigenvectors of the graph adjacency matrix. However, eigensolvers suffer from subtle problems (e.g., convergence) for ...

This paper studies how information disclosure affects the cost of equity capital (i.e., risk premium) and investors welfare in a dynamic setting with overlapping generations of investors. Our analysis demonstrates that a firm’s cost of capital decreases (increases) in the precision of public disclosure if the firm’s growth rate is below (above) a certain threshold. The threshold growth rate is ...