We have extended the study of the effects of antisense oligodeoxynucleotides on hematopoietic colony formation to include the effects of antisense to granulocyte-macrophage colony-stimulating factor (GM-CSF), granulocyte colony-stimulating factor (G-CSF), and macrophage colony-stimulating factor (M-CSF) on bone marrow cultures. GM-CSF antisense and GM-CSF receptor antisense cause an increase in...

s of the 34th Interscience Conference on Antimicrobial Agents and Chemotherapy. Orlando, FL. Washington, DC, American Society for Microbiology, 1994, p 266 (abstr H76) 148. Masucci G, Wersäll P, Ragnhammar P, Mellstedt H: Granulocytemonocyte-colony-stimulating factor augments the cytotoxic capacity of lymphocytes and monocytes in antibody dependent cellular cytotoxicity. Cancer Immunol Immunoth...

s of the 34th Interscience Conference on Antimicrobial Agents and Chemotherapy. Orlando, FL. Washington, DC, American Society for Microbiology, 1994, p 266 (abstr H76) 148. Masucci G, Wersäll P, Ragnhammar P, Mellstedt H: Granulocytemonocyte-colony-stimulating factor augments the cytotoxic capacity of lymphocytes and monocytes in antibody dependent cellular cytotoxicity. Cancer Immunol Immunoth...

Human granulocyte-macrophage colony-stimulating factor (hGM-CSF) receptor (hGMR) consists of alpha and beta subunits, and the precise stoichiometry of these subunits has remained to be determined. In this work, oligomerization of the beta subunit was studied using a chemical cross-linker. In Ba/F3, a mouse interleukin-3-dependent cell line expressing both subunits of hGMR (Ba/F3-alpha,beta), a ...

Experimental autoimmune encephalomyelitis (EAE), a model for multiple sclerosis, can be induced by immunization with a number of myelin antigens. In particular, myelin oligodendrocyte glycoprotein, a central nervous system (CNS)-specific antigen expressed on the myelin surface, is able to induce a paralytic MS-like disease with extensive CNS inflammation and demyelination in several strains of ...

We show that 1,25-dihydroxyvitamin D3 (1,25[0H12D3), the most hormonally active metabolite of vitamin 113, modulates sensitively and specifically both the protein and messenger RNA accumulation of the multilineage growth factor granulocyte-macrophage colony-stimulating factor (GM-CSF). The regulation of GMCSF expression is seen in both normal human mitogen-activated T lymphocytes and T lymphocy...