Indirect evidence for disturbed structural connectivity of subcortical fiber tracts in schizophrenia has been obtained from functional neuroimaging and electrophysiologic studies. During the past few years, new structural imaging methods have become available. Diffusion tensor imaging and magnetization transfer imaging (MTI) have been used to investigate directly whether fiber tract abnormaliti...

PURPOSE To determine whether magnetization transfer contrast can differentiate acute from chronic lesions in multiple sclerosis. METHODS Thirteen patients with multiple sclerosis and eight healthy patients were studied with MR using a 0.1-T system. Relatively T2-weighted spin-echo images were obtained without and with magnetization transfer contrast. The magnetization transfer effect of multi...

PURPOSE To determine whether magnetization transfer imaging can improve visibility of contrast enhancement of multiple sclerosis plaques. METHODS Fifty-nine enhancing and 63 nonenhancing lesions in 10 patients with multiple sclerosis were evaluated to calculate contrast-to-noise ratios on conventional T1-weighted and T1-weighted magnetization transfer images. The signal intensity of the lesio...

The value of quantitative MR methods as potential biomarkers in neuromuscular disease is being increasingly recognized. Previous studies of the magnetization transfer ratio have demonstrated sensitivity to muscle disease. The aim of this work was to investigate quantitative magnetization transfer imaging of skeletal muscle in healthy subjects at 3 T to evaluate its potential use in pathological...

Purpose: To increase the efficiency of densely encoded magnetization transfer imaging of the brain, we time-multiplex multiple slices within the same readout using simultaneous echo refocusing FLASH imaging with magnetization transfer (MT) preparation (MT-SER-FLASH). Materials and Methods: Inefficiency in total scan time results from the number of frequency samples needed for sufficient quality...

Magnetization transfer contrast has yielded insight into brain tissue microstructure changes across the lifespan and in a range of disorders. This progress has been aided by the development of quantitative magnetization transfer imaging techniques able to extract intrinsic properties of the tissue that are independent of the specifics of the data acquisition. While the tissue properties extract...

Background: Quantitative Magnetization Transfer Imaging (QMTI) is often used to quantify the myelin content in multiple sclerosis (MS) lesions and normal appearing brain tissues. Also, automated classifiers such as artificial neural networks (ANNs) can significantly improve the identification and classification processes of MS clinical datasets.Objective: We classified patients with relapsing-r...