Chronic inflammation is highly prevalent in maintenance hemodialysis (MHD) patients and associates with increased mortality. IL-1β, a pro-inflammatory cytokine, is elevated in MHD patients. A balance between IL-1β and its naturally occurring antagonist may determine the inflammatory response and its consequences in this population. We performed a pilot randomized placebo-controlled trial to eva...

BACKGROUND A decreased number of endothelial progenitor cells (EPCs) as well as anemia have been reported to be associated with cardiovascular disease. Maintenance hemodialysis (MHD) patients who require higher doses of recombinant human erythropoietin (rHuEPO) have higher cardiovascular mortality. However, it has not been examined whether there is correlation between the numbers of CD34+ cells...

BACKGROUND AND OBJECTIVES Recent in vitro studies have shown a link between alkaline phosphatase and vascular calcification in patients with chronic kidney disease (CKD). High serum levels of alkaline phosphatase are associated with increased death risk in epidemiologic studies of maintenance hemodialysis (MHD) patients. We hypothesized that coronary artery calcification is independently associ...

Only 3–5% of all patients with end-stage renal disease (ESRD) in India get some form of RRT from the existing pool of 900 nephrologists [2, 3]. As referral pattern varies widely in India for uremia therapy, there is no robust national database on the prevalence and incidence of dialysis therapy except for isolated reports. The cost of maintenance hemodialysis (MHD) for a single session varies f...

Protein calorie malnutrition is common in chronic kidney disease patients especially on maintenance hemodialysis (MHD). Multiple factors including mainly frequency and adequacy of dialysis dietary habits may result besides other comorbidities. Different tools have been designed to analyze the nutritional status subjective global assessment, inflammation score, Mini Nutritional Assessment– Short...

Objective: To assess the frequency of depression among primary caretakers maintenance hemodialysis (MHD) patients at our center and its association with different factors. Study Design: Prospective cross-sectional study. Place Duration Study: The Kidney Centre Postgraduate Training Institute Karachi, Pakistan from 1st July 2021 to 31st December 2021. Methodology: One hundred eighty-five data we...

OBJECTIVE Maintenance hemodialysis (MHD) patients often have impaired quality of life (QOL), anxiety, depression, and reduced daily physical activity (DPA) and physical performance. The contributions of these latter factors to reduced QOL in MHD are poorly understood. We examined the association of QOL with anxiety, depression, DPA, and physical performance. METHODS Seventy-two relatively hea...

BACKGROUND The mortality rate of maintenance hemodialysis (MHD) patients remains high. Measures of protein-energy wasting, including hypoalbuminemia, are strongly associated with their high mortality. Growth hormone (GH) may improve lean body mass (LBM) and serum albumin levels, and health-related quality of life (HRQoL), which are significantly and positively associated with survival in MHD pa...

Abstract Background This study aimed to determine the left ventricular (LV) systolic function in patients on maintenance hemodialysis (MHD) using myocardial work (MW) technique and investigate clinical value of MW for quantitative analysis MHD with hypertrophy (LVH). Methods A total 68 35 controls were registered this study. The divided into non-left (NLVH) group (n = 35) LVH 33) according LV m...

Background Sarcopenia is a common complication in patients undergoing maintenance hemodialysis (MHD). Growing evidence suggests close relationship between the gut microbiota and skeletal muscle. However, research on with sarcopenia MHD (MS) remains scarce. To bridge this knowledge gap, we aimed to evaluate pathogenic influence of muscle MS, clarify causal association symptoms MS identify potent...