OBJECTIVE This study was conducted to compare the tocolytic efficacy of glyceryltrinitrate (GTN) with that of magnesium sulfate (MgSO4) and to investigate serum nitric oxide metabolites before and after tocolysis. MATERIAL AND METHODS In total, 48 women between 27 and 34 weeks' gestation with threatened preterm labor and intact membranes were randomly allocated to receive either GTN or MgSO4 ...

At the present, many drugs are used for inhibition of uterine contractions, but the proportions of preterm labors are increasing. Although magnesium sulfate is the most commonly prescribed parenteral tocolytic agent, but its optimal use has yet to be delineated. In this study a high-dose protocol for magnesium sulfate tocolytic therapy was compared with a low-dose regimen. One-hundred patie...

background: preterm labor is the leading cause of infant morbidity and mortality so it may be necessary to administer tocolytics for treatment of it. objective: the aim of this study was to compare the efficacy and safety of magnesium sulfate and nifedipine in the management of preterm labor. materials and methods: 100 women with documented preterm labor were randomly assigned to receive magnes...

at present, many drugs are used for inhibition of uterine contractions, but the proportions of preterm labors are increasing. although magnesium sulfate is the most commonly prescribed parenteral tocolytic agent, but it’s optimal use has yet to be delineated. in this study a high-dose protocol for magnesium sulfate tocolytic therapy was compared with a low-dose regimen. one hundred patients adm...

Preterm labor is defined as the onset of uterine contractions in a woman who has completed less than 37 weeks of pregnancy. It may be due to maternal, placental, fetal, or idiopathic causes, and it is associated with a number of risk factors. Nondrug measures such as bedrest and hydration have been used alone or in combination with drug therapy to treat the disorder. Pharmacologic (tocolytic) a...

Background: Women with preterm labor put in an arrest phase by tocolytic therapy, are at increased risk of recurrent preterm labor. The aim of this study is to evaluate vaginal progesterone suppositories as compared to intramuscular type in order to prevent preterm labor in women with episodes of threatened preterm labor. Methods: This prospective longitudinal...

OBJECTIVES The aims were to evaluate whether any changes in blood flow in fetal inferior vena cava (IVC) are observed during Atosiban tocolysis within the first 48 hours of therapy. METHODS Detailed Doppler evaluation of blood flow in fetal IVC was performed prior to Atosiban administration and after 24 and 48 hours respectively. Maternal and fetal heart rate was assessed. IVC Doppler indices...