cutaneous leishmaniasis (cl) remains a serious public health concern in kerman province, eastern iran. this study was aimed to conduct a comprehensive review and highlights various aspects of cl in the province of kerman.this article mainly focuses on the studies published in the past 26 years on cl in the province. current data for the present status were obtained through the provincial health...

background: the purpose of this study was to evaluate antileishmanial effects of asa via no pathway in leishmania major infected balb/c mice. moreover, toxicity and pathological consequences of asa administration were investigated. methods: balb/c mice were infected with l. major and asa was inoculated orally after lesion appearance for its ability to modulate no and to modify leishmania infect...

objective: plantago major (p. major) is one of the medicinal crops in the world which has therapeutic properties for treatment of respiratory and gastrointestinal diseases. theophylline is commonly used for the treatment of respiratory diseases. in this study, we investigated the protective effects of hydro-alcoholic extract of p. majoron lung in asthmatic male rats. materials and methods: 32 m...

conclusions there was insignificant correlation between serum hepcidin and ferritin levels in the two groups of patients with tm and ti. it seems that regulation of hepcidin in patients with thalassemia is more affected by erythropoeitic activity than iron stores. also, hepcidin levels were significantly higher in patients with tm than ti, possibly due to higher erythropoeitic activity in ti. i...

various adjuvants in combination with different antigens have been utilized as a vaccine candidate against leishmaniasis. however, the search for ideal adjuvants is still pursued due to the inefficiencies of current compounds. in the present study, the effect of imiquimod, as an adjuvant, is studied with soluble leishmania antigens (sla) in balb/c mice. four groups of mice were immunized with s...

introduction: thalassemia is common in iran. appropriate therapy for this disease includes a regular blood transfusion and chelation therapy. however, patients will inevitably confront with side effects, particularly iron overloads in critical organ including heart, ductless glands and liver. this study tries to determine the prevalence of diabetes mellitus in transfusion dependent β thalassemi...

introduction: leptin is an adipocyte-derived hormone. exogenous leptin allows the recovery of the reproductive function. in humans, leptin correlates positively with the body mass index (bmi). the aim of this study was to investigate the association of leptin with the toxic effects of iron overload. methods: 219 major beta thalassemic patients (119 men, 100 women) and 137 non thalassemic indivi...

results the results obtained for each drug were compared with other drugs and also with the results of the control groups. the results related to promastigote and amastigote assays showed that when the dose of both drugs increased, the parasite number is reduced in comparison with the control groups. moreover, the parasitic burden in the test cultures decreased significantly. macrophage assay r...

background polypeptide hormone leptin suppresses inflammation in the heart muscle and protects heart from diseases. the purpose of this study is to evaluate the relationship between leptin and troponin serum levels with cardiac involvement in patients with major beta thalassemia. materials and methods in this cross-sectional study, 70 children with major thalassemia were selected. two ml blood ...