Recently, the diagnostic evaluation of pancreatic injury has improved dramatically. On the other hand, it is occasionally difficult to diagnose pancreatic injury, because there are no specific signs, symptoms, or laboratory findings. Radiological imaging also often fails to identify pancreatic injury in the acute phase. Delayed diagnosis results in significant morbidity and mortality. Most case...

BACKGROUND Major bile duct injuries occur infrequently after laparoscopic cholecystectomy, but may result in life-threatening complications. Few data exist on the financial implications of duct repair. This study calculated the costs of operative repair in a cohort of patients who underwent reconstruction of the bile duct after major ductal injury. OBJECTIVE To calculate the total in-hospital...

The Cre/loxP and Flp/FRT systems mediate site-specific DNA recombination and are being increasingly utilized to study gene function in vivo. These systems allow targeted gene disruption in a single cell type in vivo, thereby permitting study of the physiological and pathophysiological impact of a given gene product derived from a particular cell type. In the kidney, the Cre/loxP system has been...

MD also helps to spare unnecessary surgery. In patients with nipple discharge, duct excision can be avoided in those with a normal ductoscopy. Nipple-sparing mastectomy (NSM) is cosmetically superior to traditional mastectomy but there are concerns about the oncological safety with nipple-areola preservation. MD can be employed to exclude major duct involvement and this may help to select patie...

Intrabiliary growth by metastatic colorectal carcinoma (CRC) is an unusual finding that can clinically mimic cholangiocarcinoma. We evaluated prevalence of intrabiliary growth by retrospective review of 1596 diagnostic reports and by prospective evaluation of 223 hepatectomies. Positive cases were scored for extent of intrabiliary growth (major vs. minor duct involvement), architectural pattern...

Stricklett, Peter K., Raoul D. Nelson, and Donald E. Kohan. The Cre/loxP system and gene targeting in the kidney. Am. J. Physiol. 276 (Renal Physiol. 45): F651–F657, 1999.—The Cre/loxP and Flp/FRT systems mediate site-specific DNA recombination and are being increasingly utilized to study gene function in vivo. These systems allow targeted gene disruption in a single cell type in vivo, thereby ...

Pancreas is an exocrine and endocrine organ. Exocrine portion secretes digestive fluid. Endocrine secreting insulin glucagon etc. developed from dorsal ventral pancreatic buds, which arise either side of distal foregut. When duodenum rotates to right, bud(VPB) posterior along with common bile duct(CBD) finally lies below behind the bud(DPB). In humans, DPB forms major part VPB inferior head unc...

This review will briefly summarize current knowledge on the basolateral ammonia transport mechanisms in the thick ascending limb (TAL) of the loop of Henle. This segment transports ammonia against a concentration gradient and is responsible for the accumulation of ammonia in the medullary interstitium, which, in turn, favors ammonia secretion across the collecting duct. Experimental data indica...

BACKGROUND Major bile duct injury is the most worrisome complication of cholecystectomy. There is no detailed data about the incidence or treatment-related costs of bile duct injuries in Turkey. We aimed to determine prevalence and therapeutic costs of patients with major biliary duct injuries managed in our department, and further estimate a projection of these parameters at the national level...