Enzyme-linked immunosorbent assays (ELISA) for detecting malarial parasites in blood were tested on uninfected monkeys and in monkeys infected with Plasmodium falciparum. A double antibody sandwich ELISA detected one malarial cell per 10(3) uninfected cells, and an inhibition ELISA detected on infected cell per 10(4) uninfected erythrocytes. These methods are not yet as sensitive as conventiona...

Life-history theory predicts that sexually reproducing organisms have evolved to resolve resource-allocation trade-offs between growth/survival versus reproduction, and current versus future reproduction. Malaria parasites replicate asexually in their vertebrate hosts, but must reproduce sexually to infect vectors and be transmitted to new hosts. As different specialized stages are required for...

AEstivo-autumnal parasites, including the crescentic bodies, are always extracellular; that is, they are attached to the external surface of the red corpuscles. Crescentic bodies attach themselves to the red corpuscles just as the younger parasites do, by encircling, with their cytoplasm, mounds of hemoglobin substance. These hemoglobin mounds may be seen protruding through various portions of ...

(1919) regard urticaria as a manifestation of hypersensitivenes's to the malarial parasite as extremely rare. In recent years, cases showing urticaria as a result of hypersensitiveness to malarial parasites have been reported by Eyermann and Strauss (1930), Davies (1936), Gouriou (1938) and Agrama (1940) in Africa and Europe and by Chatterjee (1939) in India, who reported three cases. The case ...

formula, was prepared and successfully tested, while in the Union of Soviet Socialist Republics ' acriquine ' a similar compound was synthesized. A comparative study of the actions of these two compounds on malarial infections reveals no difference. They destroy all the stages of the three species of malarial parasites with the exception of the gametocytes of P. falciparum. Like atebrin these c...

Malnutrition including vitamin A and iron deficiency and parasitic diseases have a strikingly similar geographical distribution with the same people experiencing both insults together for much of their lives. Parasitic infections are thought to contribute to child malnutrition and micronutrient deficiency through subtle reduction in digestion and absorption, chronic inflammation and loss of nut...

Electron microscope studies of the erythrocytic forms, including gametocytes and asexual schizonts, of the protozoa Plasmodium fallax, P. lophurae, and P. cathemerium, have revealed a "cytostome," a specialized organelle of the pellicular membrane which is active in the ingestion of host cell cytoplasm. In material fixed in glutaraldehyde and postfixed in OsO(4), the cytostome appears in face v...

on 60 different occasions, and the result noted. In recording the appearances seen I only noted pigment-bearing parasites, as, although I believe I have frequently seen the clear, non-pigmented intra-corpuscular amoeboid forms of the parasite, I wished to confine myself at first to describing appearances which could only bear one interpretation. In examining the blood the procedure recommended ...