Oxidative stress and reactive oxygen species (ROS) are generated from both endogenous and environmental resources, which in turn may cause defective spermatogenesis and male infertility. Antioxidant genes, which include catalase (CAT), glutathione peroxidase (GPX), glutathione S-transferase (GST), nitric oxide synthase (NOS), nuclear factor erythroid 2-related factor 2 (NRF2), and superoxide di...

OBJECTIVE To investigate the influence of consanguineous marriage on male factor infertility in Lebanon, where rates of consanguineous marriage remain high (29.6% among Muslims, 16.5% among Christians). DESIGN Clinic-based, case-control study, using reproductive history, risk factor interview, and laboratory-based semen analysis. SETTING Two IVF clinics in Beirut, Lebanon, during an 8-month...

Male infertility has been found to be a major factor in a couple’s inability to conceive in 50% of childless marriages. There are many causes of male infertility including: deficient sperm production, blockage of ducts through which sperm are transported from the testicles, hormonal abnormalities, failure of sperm to mature properly and antisperm antibodies. Varicocele is felt to play a major r...

Unwanted childlessness affects approximately one in six couples worldwide. According to the World Health Organization, in nearly 40% of cases the cause can be attributed to the female, in 20% to the male, in 25% to both, and in 15% the cause remains unknown. The incidence of male factor infertility in the general population is approximately 7%. The majority of these men experience irreversible ...

BACKGROUND Thrombophilia-related mutations, such as coagulation factor V Leiden and factor II (G20210A), have been associated with female infertility due to spontaneous abortions during pregnancy. The possible role of mutations of these two factors in male infertility has not been studied to date. MATERIALS AND METHODS A total of 208 unrelated Greek men were investigated, including 108 infert...

Male factor infertility is common, affecting 7% of the total population and up to half of couples who are trying to conceive. Various surgical and reconstructive options allow biological paternity depending on the etiology of the male factor issues. This article describes historical treatments and newer approaches, discussing the role for traditional open surgery, microsurgery and robotic surge...