Osteosarcoma can be defined as a malignant tumor of bone in which malignant mesenchymal tumor cells have the ability to produce osteoid or immature bone. There may be profuse osteoid matrix production and extensive minealization throughout the tumor, or both may be minimal in extent and very focally distributed. The osteoblastic nature of the tumor can be easy to identify both radiographically ...

Primitive neuroectodermal tumor (PENETs) is an uncommon malignancy of bone and soft tissue witch rarely occurs in the kidney. In more than 90% of the cases, the tumor cells relieves a balanced translocation (11; 22) (q24; q12). Immunohistochemical staining may be required for diagnosis of PENET. The cells of tumor express CD99, vimentin, NSE, FL1 but do not express Ck, LCA, myogenin, and WT1. W...

Osteosarcoma refers to a bone tumor and the term was introduced by John Abernathy in 1804 referring fleshy growth [1]. In 2009, Ottaviane G. et al reported that osteosarcoma is an aggressive malignancy arises from primitive transformed cells of mesenchymal origin produces malignant osteoid, which are most common representation primary cancer [2,3].

Phyllodes tumors are rare fibroepithelial neoplasms of the breast, classified as benign, borderline, or malignant based on histological features. Osseous metaplasia, characterized by presence bone formation within tumor, is an uncommon finding. This case report highlights rarity osseous metaplasia in a benign phyllodes tumor. A 23-year-old female presented with gradually enlarging lump left bre...

Metastasis to the lymph nodes is relatively rare in malignant bone and soft-tissue tumors, and its risk factors remains unknown, except for tumors of the lymphogenous histotype, including rhabdomyosarcoma, epithelioid sarcoma, and clear cell sarcoma. The purpose of this study was to identify the risk factors for lymph node metastasis of malignant bone and soft-tissue tumors. We retrospectively ...

a malignant peripheral nerve sheath tumor (mpnst) is very rare, representing 3 - 10% of all soft tissue sarcomas. approximately half of all such tumors are diagnosed in patients with neurofibromatosis type 1 (nf1). the extremities are involved most commonly, and the patient’s age is usually 20 - 50 years. herein, we present a case of an mpnst that developed sporadically in an unusual location a...

Malignant transformation of glomus tumor is exceedingly rare and most common reported in lower extremity and abdominal viscera. We could find only 6 previous case report of malignant glomus tumor in the hand. Although large and deeply located glomus tumors are considered to be malignant, evidence has shown that most of these cases were clinically benign. These lesions are better considered as g...

introduction: ewing’s sarcoma is the second most common primary malignant tumor of bone found in children after osteosarcoma. it accounts for 4–9% of primary malignant bone tumors and it affects bones of the skull or face in only 1–4% of cases. hence it rarely affects the head and neck. subject and method: in this case report, we describe a case of primary ewing's sarcoma occurring in the tempo...

Adenoid cystic carcinoma is a rare malignant neoplasm of the salivary gland. Salivary gland neoplasms constitute 3% cancers all sites, which, 10–15% are malignant. Though adenoid most common tumor submandibular, sublingual and minor glands, it accounts for only 15% parotid cancers. They generally slow-growing spread relentlessly to adjacent structures. Hematogenous more than lymphatic spread, s...

Osteosarcoma is a relatively uncommon malignancy however, it is the most common form of primary malignant bone tumors in human. Diagnosis and prognosis of patients with osteosarcoma is limited to clinico-radiopathological parameters, whereas molecular markers of tumor aggression have been poorly identified. Survivin, an inhibitor of apoptosis (IAP), is unique for its expression in human tumors ...