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absract intracranial invasion of cellular blue nevus (cbn) from the skin is extremely rare and such a condition with malignant transformation is even rarer. a case of meningeal melanoma with malignant transformation which was derived from an ota nevus is presented in this report. a21-year-old man with a neurocutaneous syndrome since childhood was referred with headache and mild left hemiparesia...

Background: The most frequently mutated tumor suppressor gene found in human cancer is p53. In a normal situation, p53 is activated upon the induction of DNA damage to either arrest the cell cycle or to induce apoptosis. However, when mutated, p53 is no longer able to properly accomplish these functions. The aim of this study was to investigate the expression of p53 gene in cases of skin cancer...

Malignant melanoma of the oral cavity is a rare tumor that occurs due to uncontrolled growth melanocytes found in basal layer mucous membranes. Majority melanomas occur maxilla, especially on keratinizing mucosa palate and gingiva. Clinically have different types like pigmented nodular type, macular mixed non-pigmented type type. Here, we present case report 57 year old female patient with muco...

Amelanotic melanoma is met only in 28% of cases with malignant melanoma. The incidence of brain metastases in patients with malignant melanoma ranges from 643% of cases. Brain metastases are frequently associated with malignant melanoma after the intratumorale hemorrhage. We choose to present the case of 58-years-old men with a frontal brain metastasis of amelanotic malignant melanoma.

non-hodgkin lymphoma (nhl) is one of the masquerade syndromes of malignant melanoma that can occur with two main patterns of presentations in the eye: metastatic involvement of uveal tract, and primary involvement of retina. we report ophthalmic, imaging and histopathological findings in the first case diagnosed as primary choroidal nhl without central nervous system or systemic involvement. a ...

A 37-year-old woman with Klippel-Trenaunay syndrome who developed malignant melanoma on the limb affected the vascular malformation, is reported. The observation and nature of this association or coincidence is discussed.

Dear Editor-in-ChiefMalignant melanoma is a tumor arising from melanocyte; this tumor rarely occurs before puberty, with higher mortality rate in males and better survival rate in female patients affected by metastatic melanoma (1, 2). These facts propose that a relationship and association may exist between estrogens and melanoma. The effects of estrogens are mediated by...

A 75-year–old patient was referred with vaginal bleeding. Her physical exam showed two flat dark plaques on the posterior fourchette, mostly on left lateral side of the vulva. A black soft mucosal nodule was present on the left lateral side of upper vagina, and a polypoid ulcerative cervical lesion extended into the right parametrium. Cervical and vaginal biopsies were in favor of malignant mel...

a 75-year–old patient was referred with vaginal bleeding. her physical exam showed two flat dark plaques on the posterior fourchette, mostly on left lateral side of the vulva. a black soft mucosal nodule was present on the left lateral side of upper vagina, and a polypoid ulcerative cervical lesion extended into the right parametrium. cervical and vaginal biopsies were in favor of malignant mel...